Isoniazid

An antibiotic that specifically targets mycobacterium tuberculosis.

Pyrazinamide

Another antibiotic effective against actively growing m. tuberculosis.

Rifampicin

A broad-spectrum antibiotic that inhibits bacterial rna synthesis, crucial for m. tuberculosis growth.

Treatment of pulmonary tuberculosis (TB)

Treatment of extrapulmonary tuberculosis (TB affecting other organs)

This drug combination works synergistically. Isoniazid inhibits mycolic acid synthesis, Pyrazinamide disrupts bacterial metabolism, and Rifampicin blocks RNA synthesis, all vital processes for M. tuberculosis survival. This combined action increases effectiveness and reduces the risk of drug resistance.

Store in a cool, dry place, protected from light and moisture. Keep out of reach of children. Always follow the prescription instructions carefully. Do not use after the expiry date.

Dosage varies depending on age, weight, and overall health. It should always be prescribed and monitored by a physician.

Typically taken once daily, but the regimen can vary. Follow your doctor's instructions precisely.

Complete the full course of treatment, even if you feel better. Stopping early increases the risk of drug-resistant TB.

Jaundice (yellowing of the skin or eyes)

Nausea

Vomiting

Loss of appetite

Abdominal pain

Headache

Dizziness

Fatigue

Dark urine

Liver damage (rare but serious)

Druginduced hepatitis

Alcohol Consumption

Alcohol consumption should be minimized or avoided entirely while taking this medication, as it can increase the risk of liver damage.



While Driving or operating Machinery

This medication can cause dizziness or drowsiness. Avoid driving or operating machinery if affected.



Pregnant & Breastfeeding Women

Consult your doctor immediately if you are pregnant, breastfeeding, or planning to become pregnant. This medication may pass into breast milk.



Children

Dosage adjustments are necessary for children. Never administer this medication to a child without a doctor's prescription and supervision.



Kidney

Kidney impairment may necessitate dosage adjustments. Your doctor will assess your kidney function before prescribing.



Liver

Individuals with pre-existing liver conditions should be closely monitored, as the medication may cause further liver damage. Liver function tests are commonly performed during treatment.

Your physician

Prescribing information provided by the drug manufacturer

Reputable medical websites (e.g., CDC, WHO)