Imipenem is a powerful antibiotic belonging to the carbapenem class.

Cilastatin is a drug that protects imipenem from being broken down in the kidneys.

The combination of imipenem and cilastatin works together to fight bacterial infections effectively.

Treating serious bacterial infections in various parts of the body, including:

Pneumonia

Skin and soft tissue infections

Bone and joint infections

Intra-abdominal infections

Urinary tract infections

Sepsis (bloodstream infection)

Imipenem works by killing bacteria by interfering with the formation of their cell walls. Cilastatin prevents the breakdown of imipenem in the kidneys, ensuring it reaches the infection site effectively.

Store imipenem/cilastatin at room temperature, away from direct sunlight and moisture.

Dosage and frequency of administration are determined by your doctor based on the severity of your infection and your overall health.

This medicine is typically given intravenously (injected directly into a vein) over 20-30 minutes.

Your doctor will carefully monitor your response to treatment and adjust the dosage as needed.

Never change your dosage or stop taking this medication without consulting your doctor.

Nausea

Vomiting

Diarrhea

Seizures (rarely, but possible)

Allergic reactions (e.g., rash, itching, swelling)

Changes in blood cell counts

Kidney problems (rarely, but possible)

Alcohol Consumption

Alcohol consumption while on imipenem/cilastatin may increase the risk of side effects, consult your doctor.



While Driving or operating Machinery

This medication can cause dizziness or drowsiness in some people. Avoid driving or operating machinery until you know how it affects you.



Pregnant & Breastfeeding Women

This medication should only be used during pregnancy if the potential benefits outweigh the risks to the fetus. Discuss with your doctor.



Children

Safety and effectiveness in children below a certain age are not fully established. Consult your doctor.



Kidney

This medication may affect kidney function, especially in individuals with pre-existing kidney problems. Your doctor will monitor your kidney function during treatment.



Liver

This medication may affect liver function in some individuals. Your doctor will monitor your liver function during treatment.

https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/017814s022lbl.pdf

https://www.uptodate.com/contents/imipenem-and-cilastatin-drug-information