Vonoprazan

Is the active pharmaceutical ingredient (api).

Treatment of erosive reflux esophagitis (erosion of the esophagus due to stomach acid reflux)

Treatment of nonerosive reflux disease (GERD) symptoms

Maintenance of healing of erosive reflux esophagitis

Treatment of Helicobacter pylori infection (in combination with other antibiotics)

Vonostrum 20 Tab (Vonoprazan) is a potassium-competitive acid blocker (P-CAB). Unlike proton pump inhibitors (PPIs), it selectively and reversibly inhibits the gastric H+/K+-ATPase enzyme, reducing gastric acid secretion. This action is independent of the acid environment and therefore, offers rapid onset of action and consistent acid suppression.

Store at room temperature, away from direct sunlight and moisture. Keep out of reach of children.

Dosage and frequency will vary based on the indication and the patient's individual needs. Always follow your doctor's instructions.

It is typically administered orally, once daily.

Do not crush, chew, or break the tablets.

Headache

Diarrhea

Constipation

Nausea

Abdominal pain

Hypersensitivity reactions (rare)

Alcohol Consumption

The interaction between vonoprazan and alcohol is not well-established, but it's advisable to limit alcohol intake, especially during treatment.



While Driving or operating Machinery

Vonoprazan generally does not affect alertness, but patients experiencing side effects (e.g., dizziness) should avoid driving or operating machinery.



Pregnant & Breastfeeding Women

Use during pregnancy and breastfeeding is generally discouraged unless the benefits outweigh the risks. Consult your doctor.



Children

Safety and efficacy in children have not been established.



Kidney

Dose adjustments may be necessary in patients with severe kidney impairment. Consult a physician.



Liver

Dose adjustments may be necessary in patients with severe liver impairment. Consult a physician.

Please consult your physician or pharmacist for detailed information and official prescribing information (package insert).