Methotrexate

Methotrexate is the primary active ingredient.Specific formulations may contain inactive ingredients like preservatives, fillers, and stabilizers. Always check the medication label for a complete list.

Rheumatoid arthritis

Psoriatic arthritis

Juvenile idiopathic arthritis

Certain types of cancer (e.g., choriocarcinoma, nonHodgkin's lymphoma, acute lymphoblastic leukemia)

Severe psoriasis

Other autoimmune diseases (as determined by a physician)

Unitrexate 15mg Injection (Methotrexate) is an antimetabolite and antifolate. It inhibits dihydrofolate reductase, an enzyme crucial for DNA synthesis. By interfering with DNA synthesis, it slows down the rapid cell growth characteristic of cancer cells and autoimmune diseases.

Store methotrexate at room temperature, away from moisture and direct sunlight. Keep it out of reach of children and pets. Dispose of expired medication properly according to local guidelines.

Dosage is highly individualized and depends on the specific condition being treated and the patient's overall health. It's crucial to follow the instructions given by your doctor precisely.

Methotrexate is typically administered orally (as tablets or solution), intravenously, or intramuscularly. The route of administration will be determined by your physician.

Never change your dosage without consulting your physician.

Nausea and vomiting

Mouth sores

Fatigue

Headache

Loss of appetite

Diarrhea

Hair loss

Liver damage (rare but serious)

Kidney damage (rare but serious)

Bone marrow suppression (rare but serious)

Increased risk of infections

Alcohol Consumption

Alcohol consumption should be minimized or avoided entirely while taking methotrexate, as it can increase the risk of liver damage.



While Driving or Operating Machinery

Methotrexate can cause drowsiness, fatigue, or dizziness. Avoid driving or operating machinery if you experience these side effects.



Pregnant & Breastfeeding Women

Methotrexate is teratogenic (causes birth defects) and should not be taken during pregnancy. Effective contraception is crucial. It can also pass into breast milk and may harm the infant. Consult your doctor about breastfeeding while taking methotrexate.



Children

Dosage and monitoring are different in children and should be adjusted by a physician experienced in treating pediatric patients.



Kidney

Methotrexate can affect kidney function. Regular monitoring of kidney function is important, especially in patients with pre-existing kidney disease.



Liver

Methotrexate can negatively impact liver function. Liver function tests are necessary during methotrexate therapy.

Your physician's instructions

The medication's package insert

Reputable medical websites (e.g., Mayo Clinic, NHS)