Amitriptyline

A tricyclic antidepressant (tca) that affects neurotransmitters in the brain.

Propranolol

A beta-blocker that reduces the effects of adrenaline on the heart and blood vessels.

Treatment of migraine headaches (often as a preventative measure)

Management of anxiety disorders (in specific cases where both antidepressant and antianxiety effects are needed)

Treatment of certain types of chronic pain, particularly neuropathic pain (nerve pain)

Amitriptyline increases the levels of serotonin and norepinephrine in the brain, alleviating depression and pain. Propranolol blocks the effects of adrenaline, reducing heart rate, blood pressure, and migraine symptoms. The combined effect provides a synergistic approach to managing specific conditions.

Store in a cool, dry place away from direct sunlight and moisture. Keep out of reach of children. Discard any unused medication as per your pharmacist's instructions.

Dosage is highly individualized and determined by a physician based on the patient's condition and response to treatment.

The medication is typically administered orally, usually once or twice daily.

Never alter the dosage or frequency without consulting your doctor.

Drowsiness or sedation

Dry mouth

Constipation

Blurred vision

Orthostatic hypotension (dizziness upon standing)

Weight gain

Sexual dysfunction

Bradycardia (slow heart rate)

Fatigue

Nausea

Sleep disturbances (insomnia or excessive sleepiness)

Alcohol Consumption

Avoid alcohol consumption as it can potentiate the sedative effects of both medications.



While Driving or operating Machinery

Avoid driving or operating machinery until you know how this medication affects you. Drowsiness is a common side effect.



Pregnant & Breastfeeding Women

Consult your doctor immediately if you are pregnant, breastfeeding, or planning to become pregnant. The use of this combination during pregnancy and breastfeeding needs careful consideration.



Children

Not typically prescribed for children, unless specifically indicated by a physician for exceptional circumstances.



Kidney

Dosage adjustments may be necessary for individuals with impaired kidney function.



Liver

Dosage adjustments may be necessary for individuals with impaired liver function.

Consult your physician or pharmacist for complete and up-to-date information.

Refer to the official drug monograph for detailed information on Amitriptyline and Propranolol.