A sulfonylurea medication that helps your pancreas release more insulin.
A biguanide medication that helps your body use insulin more effectively.
A thiazolidinedione medication that helps your body respond better to insulin.
Type 2 diabetes mellitus (when diet and exercise alone are not enough to control blood sugar levels).
This combination medication works by improving your body's response to insulin. Glimepiride stimulates the pancreas to produce more insulin, metformin increases insulin sensitivity, and pioglitazone enhances insulin action in tissues.
Store at room temperature, away from moisture and heat. Keep out of reach of children.
Dosage is individualized based on your blood sugar levels and response to treatment.
Typically taken once daily with a meal.
Do not crush, chew, or break the tablets.
Low blood sugar (hypoglycemia)
Gastrointestinal upset (nausea, vomiting, diarrhea)
Weight gain
Fluid retention
Increased risk of bone fractures
Heart failure
Liver problems
Skin reactions
Alcohol can increase the risk of low blood sugar. Avoid excessive alcohol consumption.
Be cautious when driving or operating machinery as low blood sugar can cause dizziness or drowsiness.
This medication is not recommended for pregnant women. Consult your doctor about breastfeeding while taking this medication.
This medication is not approved for use in children.
This medication may be adjusted for patients with kidney problems. Consult your doctor.
This medication can cause liver problems. Inform your doctor if you have any liver problems or are taking other medications that may affect your liver.
Your healthcare provider
The medication's package insert
The Food and Drug Administration (FDA) website
