Metformin:

- A medication that helps lower blood sugar levels by decreasing glucose production in the liver and improving the body's response to insulin.

Linagliptin:

- A drug that belongs to a class of medications called DPP-4 inhibitors.

- It works by blocking the breakdown of a hormone called GLP-1, which helps stimulate insulin production and decrease glucagon release, leading to lower blood sugar levels.

Treatment of type 2 diabetes mellitus in adults, especially those who cannot achieve adequate glycemic control with metformin alone.

Metformin + Linagliptin acts by combining the effects of both medications. Metformin reduces glucose production in the liver and enhances insulin sensitivity, while Linagliptin increases insulin secretion and reduces glucagon release, resulting in a synergistic effect on blood sugar control.

Store at room temperature, between 15°C and 30°C (59°F and 86°F). Protect from moisture and light.

Dosage should be individualized based on the patient's blood sugar levels and response to treatment.

Typically, the initial dose is one tablet taken once daily with breakfast.

The dose can be adjusted according to the patient's needs and blood sugar monitoring results.

It is essential to take this medication regularly as prescribed by your doctor, even if you feel well.

Do not stop taking this medication without consulting your doctor.

Common side effects include:

Serious side effects are less common but can include:

Nausea

Vomiting

Diarrhea

Abdominal pain

Decreased appetite

Metallic taste in the mouth

Headache

Dizziness

Fatigue

Skin rash

Low blood sugar (hypoglycemia)

Lactic acidosis (a rare but serious condition that occurs when lactic acid builds up in the blood)

Liver problems

Pancreatitis

Severe allergic reactions

Alcohol Consumption

Alcohol consumption may increase the risk of lactic acidosis, a serious side effect of metformin. It is advisable to limit or avoid alcohol while taking this medication.



While Driving or Operating Machinery

This medication may cause dizziness or fatigue. Therefore, it is important to exercise caution while driving or operating machinery until you know how this medication affects you.



Pregnant & Breastfeeding Women

Metformin + Linagliptin is not recommended for pregnant or breastfeeding women. Talk to your doctor about safe alternatives for managing diabetes during pregnancy and breastfeeding.



Children

This medication is not intended for use in children.



Kidney

Metformin can accumulate in the blood and increase the risk of lactic acidosis in patients with kidney problems. Your doctor will monitor your kidney function closely.



Liver

Liver problems are a potential side effect of this medication. Your doctor will monitor your liver function closely.

The product information leaflet provided with the medication.

The website of the US Food and Drug Administration (FDA): https://www.fda.gov/

The website of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK): https://www.niddk.nih.gov/