Cefotaxime

Cefotaxime sodium (as the active ingredient)Various inactive ingredients depending on the formulation (e.g., sodium chloride, water for injection)

Treatment of bacterial infections caused by susceptible organisms in various parts of the body, including:

Lower respiratory tract infections (e.g., pneumonia)

Intraabdominal infections (e.g., peritonitis)

Gynecological infections (e.g., pelvic inflammatory disease)

Bacterial meningitis

Septicemia

Skin and soft tissue infections

Bone and joint infections

Tox Inj 1gm (Cefotaxime) is a broad-spectrum cephalosporin antibiotic. It works by inhibiting bacterial cell wall synthesis, thereby preventing bacterial growth and ultimately leading to bacterial cell death. It achieves this by binding to penicillin-binding proteins (PBPs), essential enzymes involved in the final stages of peptidoglycan synthesis.

Store at controlled room temperature (20°C to 25°C). Protect from light and moisture. Discard any unused portion after the expiry date.

Dosage and frequency depend on the severity of the infection, the patient's age and kidney function, and the specific infecting organism.

Cefotaxime is usually administered intravenously or intramuscularly.

Always follow your doctor's prescribed dosage and administration instructions meticulously.

In rare cases: severe allergic reactions (anaphylaxis), seizures

Nausea

Vomiting

Diarrhea

Abdominal pain

Rash

Itching

Headache

Dizziness

Elevated liver enzymes

Clostridium difficileassociated diarrhea (CDAD)

Alcohol Consumption

Alcohol consumption may exacerbate certain side effects, especially nausea and vomiting. Consult your physician regarding alcohol consumption while taking Cefotaxime.



While Driving or operating Machinery

Cefotaxime may cause dizziness or drowsiness. Avoid driving or operating machinery until you know how it affects you.



Pregnant & Breastfeeding Women

Cefotaxime should only be used during pregnancy or breastfeeding if the potential benefits outweigh the potential risks. Consult your physician.



Children

Dosage adjustments are necessary for children based on weight and age. Consult a pediatrician.



Kidney

Dosage adjustment is necessary for patients with impaired kidney function. Your doctor will monitor your kidney function during treatment.



Liver

Cefotaxime can affect liver function; liver function tests are often monitored during therapy. Patients with pre-existing liver disease may require special monitoring.

Your doctor or pharmacist

The prescribing information provided by the manufacturer

Reputable medical websites and journals (e.g., Mayo Clinic, UpToDate)