Tacrolimus is the active ingredient in the medication.It is available in various formulations, including tablets, capsules, oral solutions, and topical ointments.
Organ transplantation (kidney, liver, heart, lung, pancreas) to prevent organ rejection
Severe atopic dermatitis (eczema) when other treatments have failed
Treatment of graftversus-host disease (GVHD) after bone marrow transplantation
Treatment of psoriasis when other treatments have failed
Tacrograf 0.5mg Tab (Tacrolimus) is an immunosuppressant that works by suppressing the activity of the immune system. It binds to a protein called FKBP12, which then inhibits the production of certain signaling molecules that are important for immune cell activation. By reducing immune activity, tacrolimus helps to prevent the body from rejecting transplanted organs or attacking its own tissues in autoimmune disorders.
Store tacrolimus at room temperature, away from moisture and light. Keep it out of the reach of children and pets. Do not flush unused medication down the toilet or pour it into a drain unless instructed by your healthcare provider.
The dosage of tacrolimus is determined by your doctor and will vary based on your individual needs and the condition being treated.
Tacrolimus is typically taken twice a day, with or without food.
It is important to take tacrolimus exactly as prescribed by your doctor and to avoid missing doses.
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. Never take a double dose to make up for a missed dose.
Common side effects: Tremor, headache, nausea, vomiting, diarrhea, stomach pain, increased blood sugar, hair loss, acne, skin rash, kidney problems, high blood pressure
Serious side effects: Infection, seizures, heart problems, liver damage, diabetes, cancer, depression, suicidal thoughts
Allergic reactions: Hives, swelling of the face, lips, tongue, or throat, difficulty breathing
Avoid alcohol while taking tacrolimus as it may increase the risk of side effects.
Tacrolimus can cause drowsiness and dizziness. Avoid driving or operating machinery until you know how tacrolimus affects you.
Tacrolimus can be harmful to a developing baby. Women who are pregnant or breastfeeding should not take tacrolimus unless advised by their doctor.
The use of tacrolimus in children is not recommended unless the potential benefits outweigh the risks.
Tacrolimus can affect kidney function, so it is important to monitor your kidney function regularly while taking tacrolimus.
Tacrolimus can also affect liver function. It is important to monitor your liver function regularly while taking tacrolimus.
The United States Pharmacopeia (USP) Drug Information Portal
Drugs.com
RxList
The National Institutes of Health (NIH)
