Prescription Required.Why?
A benzodiazepine medication that acts as a central nervous system depressant, primarily used to treat anxiety and panic disorders.
A hormone naturally produced by the body, regulating sleep-wake cycles. it's often used as a supplement to improve sleep quality.
Short-term treatment of insomnia when used in combination with other sleep-promoting strategies. Note: This combination is not FDA-approved for insomnia and off-label use should only be under strict medical supervision.
Shortterm relief of anxiety symptoms (in conjunction with therapy)
Treatment of panic disorder (in conjunction with therapy)
Alprazolam enhances the effect of GABA, a neurotransmitter that inhibits neuronal activity, leading to a calming effect. Melatonin binds to melatonin receptors in the brain and other tissues, influencing circadian rhythms and promoting sleep onset. The combined effect aims for improved sleep in individuals with anxiety-related insomnia. However, the exact mechanism of the combination is not fully elucidated.
Store at room temperature away from moisture and direct sunlight. Keep out of reach of children.
Dosage should be determined by a healthcare professional and is highly individualized based on patient needs and response. There is no standard 'Alprazolam + Melatonin' formulation, thus dosage instructions will vary.
Alprazolam is typically taken orally once or twice daily. Melatonin is usually taken orally before bedtime.
Never adjust the dosage yourself. Always follow the prescription instructions precisely.
Drowsiness
Dizziness
Sedation
Confusion
Headache
Dry mouth
Nausea
Constipation
Impaired coordination
Memory problems (anterograde amnesia)
Strictly avoid alcohol consumption while taking this combination. The combined sedative effects can be dangerously synergistic.
Avoid driving or operating machinery until you know how this medication affects you. Drowsiness and impaired coordination are common side effects.
Alprazolam and melatonin should only be used during pregnancy and breastfeeding under strict medical supervision. The potential risks should be carefully weighed against the benefits.
Alprazolam is generally not recommended for children unless strictly prescribed by a pediatric specialist. Melatonin use in children requires careful consideration of dosage and potential side effects.
Reduced kidney function may affect the elimination of alprazolam, requiring dose adjustments. Consult a physician.
Reduced liver function may also affect the metabolism of alprazolam and melatonin, necessitating careful monitoring and potential dose reduction. Consult a physician.
Your healthcare provider
The FDA website
Reputable medical journals and databases (e.g., PubMed)
