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Prescription Required.
Is the active ingredient in medications like tecfidera (dimethyl fumarate extended-release capsules) and skilarence (dimethyl fumarate delayed-release capsules).
Relapsingremitting multiple sclerosis (MS)
Treatment of adults with active disease
The exact mechanism isn't fully understood, but Sclerifuma 240 Cap (Dimethyl Fumarate) is believed to modulate immune responses by affecting various pathways involved in inflammation and autoimmunity. It's thought to reduce the frequency and severity of MS relapses by reducing the production of pro-inflammatory cytokines and promoting the production of anti-inflammatory cytokines.
Store at room temperature, away from moisture and direct sunlight. Keep out of reach of children.
Dosage should be determined by a healthcare professional and may vary depending on individual factors.
Tecfidera (extended-release capsules): Typically starts with a low dose, gradually increasing to a maintenance dose.
Skilarence (delayed-release capsules): Dosage is usually once daily, but always follow prescription instructions.
Flushing (reddening of the skin)
Nausea
Gastrointestinal upset (diarrhea, vomiting)
Lymphopenia (low lymphocyte count)
Increased liver enzymes
Increased risk of infections
Moderate alcohol consumption should be discussed with your doctor. Excessive alcohol use may exacerbate side effects.
Dimethyl fumarate can cause dizziness or fatigue in some individuals. Avoid driving or operating machinery if affected.
Not recommended during pregnancy or breastfeeding unless benefits clearly outweigh risks. Discuss with your healthcare professional before conceiving or breastfeeding while on this medication.
Not approved for use in children.
Renal impairment may require dosage adjustment. Consult your doctor.
Liver function should be monitored regularly during treatment. Increased liver enzymes are a potential side effect.
Product monograph for Tecfidera/Skilarence. Please consult your local regulatory agency's drug information database for the most up-to-date prescribing information.
National MS Society Website
ClinicalTrials.gov
