Sulfate is the active ingredient in amikacin drug formulations. it is an aminoglycoside antibiotic.
Treatment of serious infections caused by susceptible gramnegative bacteria, including <em>Escherichia coli</em>, <em>Klebsiella pneumoniae</em>, <em>Pseudomonas aeruginosa</em>, and others.
Treatment of serious infections caused by susceptible grampositive bacteria (limited use).
Treatment of tuberculosis (TB) in combination with other drugs, usually when other antibiotics fail.
Rimik 500 Injection (Amikacin) works by binding to the 30S ribosomal subunit of bacteria, inhibiting protein synthesis and ultimately leading to bacterial cell death. This action is bactericidal (kills bacteria).
Store amikacin at room temperature (20°C to 25°C; 68°F to 77°F). Protect from light and moisture. Discard any unused portion after the expiry date.
Dosage depends on the severity of the infection, the patient's kidney function, and the specific bacteria involved. Always follow your doctor's prescription.
Amikacin is usually administered intravenously (IV) or intramuscularly (IM).
Treatment duration varies, ranging from a few days to several weeks, depending on the infection.
Nephrotoxicity (kidney damage): This is a major concern, especially with prolonged use or high doses.
Ototoxicity (hearing loss or balance problems)
Nausea and vomiting
Rash
Hypersensitivity reactions (allergic reactions)
Neuromuscular blockade
The effect of alcohol on amikacin treatment is unknown. It is best to avoid alcohol while taking the drug and discuss this with your doctor.
Amikacin can cause dizziness and fatigue. Avoid driving or operating machinery until you know how this medication affects you.
Amikacin should only be used during pregnancy or breastfeeding if the potential benefits outweigh the risks to the mother and fetus/infant. Consult your doctor.
Dosage adjustments are necessary for children based on weight and kidney function. Consult your pediatrician.
Amikacin is primarily excreted by the kidneys. Patients with impaired kidney function require dose adjustments to prevent toxicity. Careful monitoring of kidney function is crucial during treatment.
Amikacin's effect on the liver is generally minimal but may cause slight increases in liver enzymes in some individuals. Liver monitoring may be necessary in certain cases.
Package Insert of Amikacin (Consult your pharmacist for access)
Micromedex (Professional drug information database)
