Isoniazid

An antibiotic that specifically targets mycobacterium tuberculosis, the bacteria responsible for tuberculosis (tb).

Pyridoxine

A vitamin that helps prevent peripheral neuropathy (nerve damage) which is a side effect of isoniazid.

Rifampicin

Another antibiotic effective against mycobacterium tuberculosis. it works by inhibiting bacterial rna synthesis.

Treatment of tuberculosis (TB), specifically pulmonary and extrapulmonary TB.

Prophylaxis (prevention) of TB in individuals at high risk of infection (e.g., close contacts of TB patients).

Isoniazid and rifampicin work synergistically to inhibit the growth and kill Mycobacterium tuberculosis. Isoniazid interferes with the synthesis of mycolic acids, essential components of the bacterial cell wall. Rifampicin inhibits bacterial DNA-dependent RNA polymerase, preventing bacterial protein synthesis. Pyridoxine is included to mitigate the risk of isoniazid-induced peripheral neuropathy.

Store in a cool, dry place, away from direct sunlight and moisture. Keep out of reach of children. Discard any unused medication after the expiry date.

Dosage is determined by the physician based on the patient's age, weight, and overall health. It's crucial to follow the prescribed dosage and schedule strictly.

The medication is usually taken orally, with or without food, as directed by your doctor.

Do not stop taking the medication without consulting your doctor, even if you feel better. A complete course is essential for effective treatment.

Peripheral neuropathy (numbness or tingling in the extremities)

Nausea

Vomiting

Loss of appetite

Abdominal pain

Fatigue

Headache

Dizziness

Skin rash

Liver damage (rare but serious)

Alcohol Consumption

Alcohol consumption should be minimized or avoided while taking this medication as it can increase the risk of liver damage.



While Driving or Operating Machinery

Patients should exercise caution as dizziness and fatigue are potential side effects.



Pregnant & Breastfeeding Women

Consult your doctor before taking this medication if you are pregnant, breastfeeding, or planning to become pregnant. The benefits should outweigh the potential risks.



Children

Dosage is adjusted based on the child's weight and age. Always follow the doctor's instructions.



Kidney

Patients with kidney impairment may require dosage adjustments. The doctor should be informed of any kidney conditions.



Liver

Patients with liver disease should be closely monitored, as this medication can impact liver function. Regular liver function tests may be necessary.

Consult your physician or pharmacist for detailed information and specific references.