Sildenafil

Is the active ingredient in medications like viagra, revatio, and others. it belongs to a class of drugs called phosphodiesterase type 5 (pde5) inhibitors. these medications work by relaxing the muscles in the walls of blood vessels, allowing more blood to flow into the penis and helping to achieve an erection. in some formulations, sildenafil may be combined with other ingredients for specific purposes, such as in combination with dapoxetine for premature ejaculation.

Sildenafil is primarily prescribed for erectile dysfunction (ED), a condition where a man is unable to achieve or maintain an erection sufficient for sexual intercourse.

It can also be prescribed for pulmonary arterial hypertension (PAH), a condition where the blood pressure in the arteries of the lungs is abnormally high.

In some cases, it may be used offlabel for other conditions like Raynaud's phenomenon.

It's crucial to consult your doctor to determine the appropriate use of sildenafil for your specific health condition.

0 Pulmosil Inj 12.5ml (Sildenafil) works by inhibiting the enzyme PDE5, which is responsible for breaking down cyclic guanosine monophosphate (cGMP).1 cGMP is a molecule that relaxes smooth muscle cells in the blood vessels, allowing for increased blood flow.2 By inhibiting PDE5, sildenafil allows cGMP to remain active for longer, leading to relaxation of the smooth muscle cells in the blood vessels of the penis, enhancing blood flow and facilitating an erection.3 In the case of PAH, sildenafil works by relaxing the blood vessels in the lungs, reducing blood pressure and improving blood flow.

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Store sildenafil at room temperature, away from moisture and direct sunlight.

1

Keep it out of reach of children and pets.

2

Do not use the medication after the expiration date printed on the label.

3

Dispose of expired or unused medication properly, following your pharmacist's instructions.

The dosage of sildenafil varies depending on the condition being treated and individual patient factors.

Your doctor will determine the appropriate dosage for you.

For erectile dysfunction, sildenafil is typically taken 30-60 minutes before sexual activity.

It can be taken with or without food, but taking it with a high-fat meal may delay the onset of action.

It's essential to strictly follow your doctor's instructions and not exceed the prescribed dosage.

Do not crush, chew, or break the tablet unless directed by your doctor.

More serious side effects, although rare, may include chest pain, sudden vision loss, prolonged erection (priapism), and hearing loss.

Common side effects include headache, flushing, indigestion, nasal congestion, and vision changes.

Alcohol Consumption

Consuming alcohol while taking sildenafil can increase the risk of side effects, especially low blood pressure. Limit alcohol intake while taking this medication.



While Driving or Operating Machinery

Sildenafil may cause dizziness, blurred vision, and drowsiness in some individuals. Avoid driving or operating machinery if you experience these effects.



Pregnant & Breastfeeding Women

Sildenafil is not intended for use by pregnant or breastfeeding women. It is not known if the medication passes into breast milk, so it is best to avoid breastfeeding while taking sildenafil.



Children

Sildenafil is not approved for use in children.



Kidney

Individuals with kidney problems may need lower doses of sildenafil. Your doctor will adjust the dosage based on your kidney function.



Liver

Individuals with liver problems may also need lower doses of sildenafil. Your doctor will adjust the dosage based on your liver function.

https://www.medicines.org.uk/emc/medicine/2448/pil

https://www.drugs.com/sildenafil.html

https://www.mayoclinic.org/diseases-conditions/erectile-dysfunction/symptoms-causes/syc-20355776

https://www.nhs.uk/conditions/erectile-dysfunction/treatment/