Conjugated Estrogens

Conjugated estrogens are a mixture of estrogens derived from pregnant mares' urine. The specific composition can vary slightly between brands.Each formulation will list the specific estrogen types and their amounts (e.g., estrone sulfate, equilin sulfate, 17α-dihydroequilin sulfate, 17β-estradiol).

Treatment of moderate to severe vasomotor symptoms (hot flashes) associated with menopause.

Treatment of atrophic vaginitis (vaginal dryness and inflammation).

Prevention of osteoporosis in postmenopausal women at high risk of fractures (usually used in conjunction with other osteoporosis therapies).

Premarin 0.625 Tab (Conjugated Estrogens) replace the estrogen that the body produces naturally following menopause. This replacement helps alleviate symptoms associated with estrogen deficiency, including hot flashes, vaginal atrophy, and bone loss.

Store at room temperature, away from moisture and direct sunlight. Keep out of reach of children. Discard any unused medication as directed by your pharmacist or healthcare provider.

Dosage varies depending on the specific condition being treated and the individual's response. Always follow the directions on your prescription label or as directed by your healthcare provider.

Conjugated estrogens are typically administered orally.

Changes in menstrual bleeding (if not postmenopausal)

Blood clots (deep vein thrombosis, pulmonary embolism)

Breast tenderness

Fluid retention

Headache

Nausea

Vomiting

Leg cramps

Gallbladder disease

Alcohol Consumption

The interaction between alcohol and conjugated estrogens isn't well-defined, but excessive alcohol consumption should be avoided as it can increase the risk of liver damage and other health problems.



While Driving or Operating Machinery

Drowsiness or dizziness are potential side effects. Avoid driving or operating machinery if experiencing these symptoms.



Pregnant & Breastfeeding Women

Conjugated estrogens are contraindicated during pregnancy and breastfeeding. Use of this medication may harm the fetus or infant.



Children

Not indicated for use in children.



Kidney

Patients with impaired kidney function may require dose adjustment or monitoring.



Liver

Patients with impaired liver function may require dose adjustment or monitoring. Conjugated estrogens are metabolized by the liver.

Your prescribing healthcare provider.

The prescribing information leaflet included with your medication.

Reputable medical websites like the FDA or Mayo Clinic.