Pregabalin is an anticonvulsant medication that is used to treat seizures, nerve pain, and anxiety.

Duloxetine is a serotonin-norepinephrine reuptake inhibitor (SNRI) that is used to treat depression, anxiety, and chronic pain.

Treatment of generalized anxiety disorder (GAD)

Treatment of diabetic peripheral neuropathy (nerve pain in the feet and legs)

Treatment of fibromyalgia (a disorder that causes widespread musculoskeletal pain, fatigue, and sleep problems)

Treatment of chronic musculoskeletal pain

Treatment of major depressive disorder (MDD)

Pregabalin works by reducing the release of certain chemicals in the brain that are involved in the transmission of pain signals. Duloxetine works by increasing the levels of serotonin and norepinephrine in the brain. These neurotransmitters are involved in regulating mood, sleep, appetite, and pain.

Store the medication at room temperature, away from heat and light. Keep it out of reach of children and pets.

The dosage of pregabalin and duloxetine will vary depending on the individual patient's condition and response to treatment.

It is important to follow the instructions provided by your doctor carefully.

The medication is typically taken by mouth, with or without food.

The dosage of pregabalin is usually started at a low dose and gradually increased over time.

The dosage of duloxetine is typically started at a low dose and gradually increased over time.

Drowsiness

Dizziness

Headache

Nausea

Dry mouth

Constipation

Blurred vision

Weight gain

Increased appetite

Sexual problems

Withdrawal symptoms (if stopped abruptly)

Alcohol Consumption

It is important to avoid alcohol while taking pregabalin and duloxetine. Alcohol can increase the risk of drowsiness and dizziness.



While Driving or Operating Machinery

Do not drive or operate machinery until you know how this medication affects you. Pregabalin and duloxetine can cause drowsiness and dizziness.



Pregnant & Breastfeeding Women

Pregabalin and duloxetine can pass into breast milk and may harm a nursing infant. It is important to talk to your doctor about the risks and benefits of taking this medication if you are pregnant or breastfeeding.



Children

Pregabalin and duloxetine are not typically prescribed for children.



Kidney

Pregabalin and duloxetine are eliminated from the body through the kidneys. If you have kidney problems, you may need a lower dose of these medications.



Liver

Pregabalin and duloxetine are metabolized by the liver. If you have liver problems, you may need a lower dose of these medications.

https://www.medicines.org.uk/

https://www.nhs.uk/

https://www.mayoclinic.org/

https://www.fda.gov/