Pioglitazone: A type of medication called a thiazolidinedione (TZD), which works by increasing the sensitivity of your body's cells to insulin.

Metformin: A medication that belongs to a class of drugs known as biguanides. It helps control blood sugar levels by decreasing the amount of glucose your liver produces and by improving your body's response to insulin.

Type 2 diabetes mellitus (T2DM) when diet and exercise alone have not been enough to control blood sugar levels.

Pioglitazone and metformin work together to improve blood sugar control in people with type 2 diabetes. Pioglitazone helps your body use insulin more effectively, while metformin helps reduce the amount of sugar your liver produces.

Store this medication at room temperature, away from light and moisture. Keep it out of reach of children and pets.

The dosage of pioglitazone and metformin will be determined by your doctor based on your individual needs and response to treatment.

It is typically taken orally, usually once or twice daily with meals.

Follow your doctor's instructions carefully and do not change your dosage or stop taking the medication without consulting your doctor.

More serious side effects can occur, such as: heart failure, liver problems, and bladder cancer. It's important to contact your doctor immediately if you experience any unusual or serious side effects.

Common side effects may include: nausea, diarrhea, stomach upset, weight loss, headache, fluid retention, and anemia.

Alcohol Consumption

Avoid excessive alcohol consumption while taking this medication as it can increase the risk of liver problems.



While Driving or Operating Machinery

This medication may cause dizziness or lightheadedness. Avoid driving or operating machinery until you know how this medication affects you.



Pregnant & Breastfeeding Women

This medication should not be taken during pregnancy as it may harm the fetus. It's also not recommended for breastfeeding women as it can pass into breast milk.



Children

This medication is not approved for use in children.



Kidney

This medication may be harmful to your kidneys, especially if you have kidney problems. Your doctor may need to monitor your kidney function while you are taking this medication.



Liver

This medication may cause liver problems. Your doctor may need to monitor your liver function while you are taking this medication.

https://www.mayoclinic.org/diseases-conditions/type-2-diabetes/diagnosis-treatment/drc-20351199

https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-fda-requires-boxed-warning-pioglitazone-thiazolidinediones-tzds-increase-risk-heart

https://www.ncbi.nlm.nih.gov/pubmed/22013549