A broad-spectrum antibiotic effective against a wide range of bacteria.
An antibiotic effective against gram-negative bacteria, particularly pseudomonas aeruginosa.
Treatment of serious bacterial infections where both Grampositive and Gram-negative bacteria are suspected or confirmed, especially when other antibiotics have failed.
Ophthalmic use in some formulations (this specific formulation's use must be confirmed with a medical professional).
Chloramphenicol inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. Polymyxin B disrupts bacterial cell membranes, leading to cell death. The combination provides broader coverage against a wider range of bacterial strains.
Store at a controlled room temperature (20-25°C) away from direct sunlight and moisture. Keep out of reach of children. Discard any unused medication after the expiration date.
Dosage and administration will vary significantly based on the specific formulation, the patient's age, weight, and the severity of the infection.
Always follow the prescription instructions provided by your doctor. Do not exceed the prescribed dose.
Never self-medicate. This information is for educational purposes and should not replace medical advice.
Bone marrow suppression (aplastic anemia, a serious and potentially fatal side effect of chloramphenicol).
Neurotoxicity (headache, dizziness, confusion; more likely with high doses).
Gastrointestinal issues (nausea, vomiting, diarrhea).
Allergic reactions (rash, itching, swelling).
Avoid alcohol consumption while taking this medication, as it may exacerbate side effects.
Caution advised, as side effects like dizziness and confusion may impair alertness.
Consult your doctor immediately, as chloramphenicol can pass into breast milk and potentially harm the fetus or infant. It's generally avoided during pregnancy.
Use in children is usually only considered in severe infections where benefits outweigh risks and under strict medical supervision.
Use with caution in patients with impaired kidney function, as the medication may accumulate in the body.
Use with caution in patients with impaired liver function, as it may impact metabolism and increase the risk of side effects.
Consult your doctor or pharmacist for complete prescribing information. Specific references to package inserts and clinical studies will vary by formulation and country.
