Bortezomib

Bortezomib is the active ingredient in the medication.It is a proteasome inhibitor, meaning it blocks the activity of proteasomes within cells.Proteasomes are responsible for breaking down proteins in cells, and bortezomib disrupts this process, leading to cell death in certain types of cancer cells.

Multiple myeloma (a type of blood cancer)

Mantle cell lymphoma (a type of nonHodgkin's lymphoma)

Certain types of Waldenström macroglobulinemia (a type of blood cancer)

Norvelzo 3.5mg Injection (Bortezomib) works by inhibiting the activity of proteasomes, which are responsible for breaking down proteins in cells. This disruption leads to the accumulation of proteins in the cell, ultimately causing cell death. Bortezomib primarily targets cancer cells, as they are more sensitive to proteasome inhibition than healthy cells.

Store bortezomib at room temperature, away from heat, light, and moisture. Keep the medication in its original container and keep it out of reach of children and pets.

The dosage of bortezomib is determined by your doctor based on your individual health condition and response to treatment.

Bortezomib is usually administered intravenously (by injection into a vein) or subcutaneously (by injection under the skin).

The frequency of administration can vary depending on the specific treatment regimen.

Peripheral neuropathy (numbness or tingling in the hands and feet)

Nausea

Vomiting

Diarrhea

Constipation

Fatigue

Weakness

Skin rash

Fluid retention

Heart problems (including heart failure)

Liver problems

Alcohol Consumption

It is important to talk to your doctor about whether it is safe to consume alcohol while taking bortezomib.



While Driving or Operating Machinery

Bortezomib may cause drowsiness, dizziness, or other side effects that can impair your ability to drive or operate machinery. Do not drive or operate machinery until you know how this medication affects you.



Pregnant & Breastfeeding Women

Bortezomib is not recommended for use during pregnancy as it can harm the developing fetus. It is also not recommended for use during breastfeeding, as it can pass into breast milk and harm the infant. Talk to your doctor about birth control options and potential risks while taking bortezomib.



Children

Bortezomib is not approved for use in children.



Kidney

Bortezomib can be harmful to the kidneys. Your doctor will monitor your kidney function while you are taking this medication.



Liver

Bortezomib can be harmful to the liver. Your doctor will monitor your liver function while you are taking this medication.

https://www.drugs.com/mtm/bortezomib.html

https://www.mayoclinic.org/diseases-conditions/multiple-myeloma/diagnosis-treatment/drc-20352504

https://www.cancer.gov/publications/dictionaries/cancer-terms/def/proteasome-inhibitor