Lamivudine

A nucleoside reverse transcriptase inhibitor (nrti) that prevents hiv from replicating.

Treatment of HIV1 infection in adults and children. This combination is typically used as part of a broader antiretroviral therapy (ART) regimen.

This combination therapy utilizes three different antiretroviral agents with distinct mechanisms to inhibit HIV replication. Lamivudine and Stavudine interfere with the HIV enzyme reverse transcriptase, preventing it from converting viral RNA into DNA, a necessary step for viral replication. Nevirapine also inhibits reverse transcriptase, but through a different mechanism. By combining these drugs, they reduce the likelihood of HIV developing resistance.

Store at room temperature (below 30°C) and protect from moisture. Discard any unused medicine appropriately as per local guidelines. Do not use past the expiration date.

Dosage must be determined by a healthcare professional based on individual patient factors. It is crucial to adhere strictly to the prescribed dosage regimen.

Typical regimens usually involve taking the medication orally once or twice daily, depending on the formulation and patient-specific circumstances.

Always follow your doctor's instructions precisely regarding when and how to take the medication.

Peripheral neuropathy (tingling or numbness in hands and feet, particularly with stavudine)

Nausea

Vomiting

Diarrhea

Headache

Fatigue

Rash

Hepatotoxicity (liver damage)

Pancreatitis (inflammation of the pancreas)

Alcohol Consumption

Alcohol may increase the risk of liver damage; avoid excessive alcohol consumption.



Driving or operating Machinery

Drowsiness or dizziness may occur; avoid driving or operating machinery if affected.



Pregnant & Breastfeeding Women

Consult a doctor immediately. This combination therapy has potential risks during pregnancy and breastfeeding. Alternative regimens may be considered.



Children

Dosage must be adjusted according to weight and age; under strict medical supervision.



Kidney

Kidney impairment may affect drug elimination; dosage adjustment may be necessary.



Liver

Liver function should be monitored regularly. This combination can affect liver function, particularly with pre-existing liver conditions.

Please consult your healthcare provider or refer to official drug information sources such as the prescribing information provided by the manufacturer.