Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing hormones that cause pain and swelling in the body.

Esomeprazole is a proton pump inhibitor (PPI) that works by decreasing the amount of acid produced in the stomach.

The combination of naproxen and esomeprazole is used to treat pain and inflammation caused by osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.

It also helps to prevent ulcers in the stomach and intestines that may be caused by NSAIDs.

Pain and inflammation caused by osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis

Prevention of ulcers in the stomach and intestines that may be caused by NSAIDs

Naproxen, an NSAID, reduces inflammation and pain by inhibiting the production of prostaglandins, hormone-like substances that cause pain and inflammation. Esomeprazole, a PPI, reduces stomach acid by blocking the enzyme responsible for acid production. This combined action provides relief from pain and inflammation while protecting the stomach and intestines from the potential ulcer-causing effects of NSAIDs.

Store at room temperature, between 68-77 degrees Fahrenheit (20-25 degrees Celsius). Protect from light and moisture. Keep out of reach of children.

The dosage of naproxen and esomeprazole will vary depending on your individual needs and medical condition.

It is important to follow your doctor's instructions carefully.

This medication is typically taken with food.

Do not crush or chew the tablets. Swallow them whole with a glass of water.

Heartburn

Nausea

Diarrhea

Constipation

Gas

Abdominal pain

Headache

Dizziness

Stomach upset

Skin rash

Alcohol Consumption

Alcohol may increase the risk of stomach bleeding. It is best to avoid alcohol while taking naproxen and esomeprazole.



While Driving or operating Machinery

This medication may cause dizziness or drowsiness. Avoid driving or operating machinery until you know how this medication affects you.



Pregnant & Breastfeeding Women

It is not known if this medication is safe to use during pregnancy or while breastfeeding. Talk to your doctor before taking this medication if you are pregnant or breastfeeding.



Children

This medication is not approved for use in children.



Kidney

This medication can cause kidney problems, especially if you already have kidney disease. Talk to your doctor before taking this medication if you have kidney disease.



Liver

This medication can cause liver problems. Talk to your doctor before taking this medication if you have liver disease.

https://www.mayoclinic.org/drugs-supplements/naproxen-oral-route/description/drg-20069729

https://www.drugs.com/mtm/esomeprazole.html

https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-fda-requires-labeling-changes-proton-pump-inhibitors-ppis-reduce-risk-fractures-hip-wrist-spine