Primidone

Is the active ingredient.

Treatment of tonicclonic seizures (grand mal seizures)

Treatment of focal seizures (partial seizures)

Treatment of myoclonic seizures (brief, involuntary muscle jerks)

Sometimes used as an adjunctive therapy in the treatment of other seizure types

Mysoline 250mg Tab (Primidone) is a prodrug that is metabolized in the liver to phenobarbital and phenylethylmalonamide (PEMA). Phenobarbital enhances the inhibitory effects of GABA (gamma-aminobutyric acid), a neurotransmitter that reduces neuronal excitability, thus suppressing seizures. PEMA also contributes to the anticonvulsant effects, though its precise mechanism is less understood.

Store at room temperature, away from moisture and direct sunlight. Keep out of reach of children. Discard any unused medication after the expiry date.

Dosage is individualized based on the patient's age, weight, seizure type, and response to treatment.

Dosage is typically started low and gradually increased under close medical supervision.

Primidone is usually administered orally, as tablets.

Always follow your doctor's instructions carefully regarding dosage and frequency.

Drowsiness

Dizziness

Unsteadiness (ataxia)

Nausea

Vomiting

Fatigue

Confusion

Depression

Skin rash

Blood disorders (rare but serious)

Alcohol Consumption

Avoid alcohol consumption as it can enhance the sedative effects of primidone, leading to increased drowsiness and impaired coordination.



While Driving or operating Machinery

Avoid driving or operating machinery until you know how primidone affects you. Drowsiness and dizziness are common side effects.



Pregnant & Breastfeeding Women

Inform your doctor immediately if you are pregnant, planning to become pregnant, or breastfeeding. Primidone can cross the placenta and be excreted in breast milk.



Children

Dosage adjustments are necessary for children. Close monitoring is crucial.



Kidney

Primidone is primarily metabolized by the liver; however, renal impairment may affect the elimination of its metabolites. Dosage adjustments may be needed in patients with severe kidney disease.



Liver

Primidone is extensively metabolized by the liver. Patients with liver disease require careful monitoring and potential dosage adjustments.

Your physician

Prescribing information from the medication manufacturer

Reputable medical websites such as the FDA or national health agencies.