Methotrexate: A disease-modifying antirheumatic drug (DMARD) that suppresses the immune system.

Folic Acid: A synthetic form of vitamin B9, which is essential for cell growth and DNA synthesis.

Rheumatoid arthritis (RA)

Psoriatic arthritis

Ankylosing spondylitis

Juvenile idiopathic arthritis

Crohn's disease

Ulcerative colitis

Certain types of cancer, such as leukemia and lymphoma

Severe psoriasis

Methotrexate works by slowing down the growth of cells that cause inflammation and damage in the body. Folic acid is given to help prevent certain side effects of methotrexate, such as low red blood cell count (anemia).

Store methotrexate tablets at room temperature, away from moisture and heat. Keep methotrexate solution refrigerated. Do not freeze.

The dosage of methotrexate and folic acid varies depending on the condition being treated and the individual's response.

Methotrexate is typically taken once a week, usually on the same day each week.

Folic acid is usually taken daily, but may be taken more frequently in some cases.

It is important to take methotrexate and folic acid exactly as prescribed by your doctor.

Nausea and vomiting

Diarrhea

Headache

Fatigue

Mouth sores

Hair loss

Liver damage

Increased risk of infection

Lung problems

Alcohol Consumption

Avoid excessive alcohol consumption while taking methotrexate, as it can increase the risk of liver damage.



While Driving or Operating Machinery

Methotrexate can cause fatigue, dizziness, and drowsiness. Avoid driving or operating machinery if you experience these side effects.



Pregnant & Breastfeeding Women

Methotrexate is a teratogen, meaning it can cause birth defects. It is highly dangerous for pregnant women to take methotrexate. It is also not recommended to breastfeed while taking methotrexate. Discuss your options with your healthcare provider.



Children

The use of methotrexate in children is generally safe and effective, but it is important to follow the dosage instructions carefully and monitor for side effects.



Kidney

Methotrexate can be toxic to the kidneys. People with kidney problems may need a lower dose of methotrexate or more frequent monitoring.



Liver

Methotrexate can cause liver damage. People with liver problems may need a lower dose of methotrexate or more frequent monitoring.

National Institutes of Health (NIH): https://www.ncbi.nlm.nih.gov/

American College of Rheumatology (ACR): https://www.rheumatology.org/

Food and Drug Administration (FDA): https://www.fda.gov/