Mesalazine

Mesalazine, also known as mesalamine, is the active ingredient in medications used to treat inflammatory bowel diseases (IBDs) such as ulcerative colitis and Crohn's disease.It is available in various formulations, including oral tablets, capsules, granules, and rectal suppositories or enemas.The specific inactive ingredients may vary depending on the brand and formulation.

Ulcerative colitis

Crohn's disease (mainly for leftsided or distal ileitis)

Maintaining remission of ulcerative colitis

Mesacol Enema 60ml (Mesalazine) is an aminosalicylate drug that works by reducing inflammation in the digestive tract. It is thought to work by inhibiting the production of inflammatory substances, such as prostaglandins, leukotrienes, and cytokines.

Store mesalazine medication at room temperature, away from moisture and heat. Keep it in its original container.

The dosage of mesalazine will vary depending on the severity of your condition, your age, and your overall health. Your doctor will determine the best dosage for you.

Mesalazine is typically taken orally, but it can also be administered rectally as a suppository or enema.

It is important to follow your doctor's instructions carefully regarding the frequency and timing of your doses.

Do not stop taking mesalazine without first talking to your doctor.

Gastrointestinal problems: Nausea, vomiting, diarrhea, abdominal pain

Headache

Dizziness

Rash

Hair loss

Liver problems

Kidney problems

Low white blood cell count (neutropenia)

Severe allergic reaction

Alcohol Consumption

It is generally safe to consume alcohol in moderation while taking mesalazine. However, alcohol may worsen some gastrointestinal side effects.



While Driving or operating Machinery

Mesalazine may cause dizziness or drowsiness in some people. It is important to avoid driving or operating machinery until you know how this medication affects you.



Pregnant & Breastfeeding Women

Mesalazine is generally considered safe for use during pregnancy, but it should only be taken under the guidance of a doctor. It is unknown whether mesalazine passes into breast milk, so caution is advised if breastfeeding.



Children

The safety and effectiveness of mesalazine in children have not been established. It should only be used in children under the guidance of a doctor.



Kidney

Mesalazine can affect kidney function in some people. Your doctor may monitor your kidney function during treatment.



Liver

Mesalazine can affect liver function in some people. Your doctor may monitor your liver function during treatment.

https://www.mayoclinic.org/diseases-conditions/ulcerative-colitis/diagnosis-treatment/drc-20353551

https://www.ncbi.nlm.nih.gov/pubmed/11115054

https://www.webmd.com/drugs/2/drug-12422/mesalamine-oral/details