Citrate the active pharmaceutical ingredient responsible for the medication's effects.
Erectile Dysfunction (ED): Treatment of impotence in adult men.
Pulmonary Arterial Hypertension (PAH): Treatment of PAH in adults, usually in combination with other medications.
Macsutra 100mg Tab (Sildenafil) inhibits phosphodiesterase type 5 (PDE5), an enzyme that breaks down cyclic GMP. Increased cyclic GMP levels relax smooth muscles in the blood vessels of the penis, leading to improved blood flow and facilitating erection in the case of ED. In PAH, this mechanism improves blood flow in the pulmonary arteries, reducing blood pressure.
Store at room temperature, away from moisture and direct sunlight. Keep out of reach of children.
Dosage varies depending on the condition being treated and individual patient factors. Always follow your doctor's instructions.
For ED, a typical starting dose is 50mg taken as needed, approximately 1 hour before sexual activity. The dose may be adjusted based on efficacy and tolerability.
For PAH, dosage is prescribed by a physician and typically involves a daily regimen.
Visual disturbances (blurred vision, changes in color perception)
Rarely: more serious cardiovascular events such as chest pain or irregular heartbeat
Headache
Facial flushing
Nasal congestion
Dyspepsia (indigestion)
Muscle aches
Back pain
Dizziness
Alcohol may enhance side effects. Limit alcohol intake while taking sildenafil.
Sildenafil may cause dizziness or visual disturbances, which may impair ability to drive or operate machinery. Avoid these activities if affected.
Not indicated for use in women. Consult your doctor.
Not indicated for use in children.
Patients with severe kidney disease may require dosage adjustments.
Patients with severe liver disease may require dosage adjustments.
Your physician
The medication's package insert
Reputable medical websites (e.g., Mayo Clinic, NIH)
