Sitagliptin: A dipeptidyl peptidase-4 (DPP-4) inhibitor that helps the body release more insulin when needed and reduces the production of excess glucose.

Metformin: A biguanide that lowers blood glucose levels by decreasing glucose production in the liver and improving insulin sensitivity.

Treatment of type 2 diabetes mellitus in adults, particularly when metformin alone is insufficient to control blood sugar levels.

Sitagliptin works by inhibiting the DPP-4 enzyme, which normally breaks down incretins (hormones that stimulate insulin release). By inhibiting DPP-4, sitagliptin increases incretin levels, leading to improved glucose control. Metformin works by reducing glucose production in the liver, increasing insulin sensitivity in muscle tissue, and decreasing glucose absorption in the gut. The combination provides a synergistic effect on blood glucose management.

Store at room temperature, below 30°C (86°F), in a dry place, away from direct sunlight and moisture. Keep out of reach of children.

Dosage should be determined by a healthcare professional based on individual needs and response to treatment.

Generally, it is recommended to start with a low dose and gradually increase it as needed.

Always follow your doctor's instructions carefully and do not alter your dosage without consulting them.

Less Common: Hypoglycemia (low blood sugar), allergic reactions (rash, itching, swelling), lactic acidosis (rare but serious).

Note: This is not an exhaustive list. Consult your doctor or pharmacist if you experience any concerning side effects.

Common: Nausea, vomiting, diarrhea, abdominal pain, headache, dizziness, upper respiratory tract infection.

Alcohol Consumption

Alcohol consumption may increase the risk of hypoglycemia and lactic acidosis. Limit alcohol intake while taking this medication.



Driving or Operating Machinery

May cause dizziness or lightheadedness. Avoid driving or operating machinery if affected.



Pregnant & Breastfeeding Women

Not recommended during pregnancy. Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding.



Children

Not indicated for use in children.



Kidney

Caution is advised in patients with kidney disease. Dosage adjustment may be necessary.



Liver

Caution is advised in patients with liver disease. Dosage adjustment may be necessary.

Please consult your doctor or pharmacist for specific references and further information regarding the medication.