Pyrazinamide

Pyrazinamide is the main active ingredient.Specific formulations may contain additional excipients (inactive ingredients) such as fillers, binders, and coatings. Always check the specific product label for a complete list.

Pyrazinamide is primarily used in the treatment of tuberculosis (TB), specifically in combination with other antituberculosis drugs.

Macrozide 750mg Tab (Pyrazinamide) is a bacteriostatic antibiotic that inhibits the growth of Mycobacterium tuberculosis. Its exact mechanism isn't fully understood, but it's thought to interfere with bacterial metabolism by disrupting fatty acid synthesis and potentially through other mechanisms.

Store pyrazinamide at room temperature, away from moisture and direct sunlight. Keep out of reach of children.

Dosage is determined by a healthcare professional and depends on factors such as the patient's weight, age, overall health, and the severity of the infection.

Pyrazinamide is typically administered orally, usually as a tablet or capsule.

Always follow the prescribed dosage and duration of treatment precisely as directed by your doctor.

Liver damage (hepatotoxicity) – this is a serious side effect and requires monitoring.

Elevated uric acid levels (hyperuricemia) leading to gout.

Nausea

Vomiting

Loss of appetite

Abdominal pain

Joint pain

Rash

Photosensitivity (increased sensitivity to sunlight).

Alcohol Consumption

Alcohol consumption may increase the risk of liver damage while taking pyrazinamide. It is advisable to avoid or limit alcohol intake during treatment.



While Driving or operating Machinery

Pyrazinamide may cause drowsiness or dizziness in some individuals. Avoid driving or operating machinery if you experience these side effects.



Pregnant & Breastfeeding Women

Use during pregnancy and breastfeeding is generally avoided unless the benefits outweigh the potential risks. Consult your doctor.



Children

Dosage and safety in children are determined by the prescribing physician. It's not routinely used in young children due to potential side effects.



Kidney

Patients with impaired kidney function may require dosage adjustments to prevent toxic accumulation. Kidney function should be monitored regularly during treatment.



Liver

Pyrazinamide can cause liver damage. Regular liver function tests are crucial during treatment to detect any abnormalities.

Your prescribing physician.

The official drug monograph (if available in your country).

Reputable medical websites such as the CDC or WHO for general information on tuberculosis treatment.