Prescription Required.Why?
Is the active ingredient.
Treatment of tuberculosis (TB), typically in combination with other antiTB drugs.
Specifically used in the intensive phase of TB treatment.
Macrozide 1500mg Tab (Pyrazinamide) is a bacteriostatic or bactericidal drug that inhibits bacterial growth and/or kills Mycobacterium tuberculosis. Its exact mechanism is not fully understood, but it's believed to interfere with bacterial fatty acid synthesis and disrupt mycolic acid production, essential components of the mycobacterial cell wall.
Store at room temperature (20-25°C) in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Dosage is determined by the physician based on factors including patient weight, age, and overall health.
Usually administered orally, typically once daily.
The duration of treatment is dependent on the clinical response and the specific treatment regimen.
Hepatotoxicity (liver damage): This is the most serious side effect and requires close monitoring.
Nausea
Vomiting
Loss of appetite
Arthralgia (joint pain)
Hyperuricemia (elevated uric acid levels)
Rash
Photosensitivity (increased sensitivity to sunlight)
Alcohol consumption should be avoided or minimized as it can increase the risk of liver damage.
Patients should exercise caution as dizziness or other side effects might impair their ability to drive or operate machinery.
Use during pregnancy and breastfeeding should be carefully considered by the physician, weighing potential benefits against risks to the fetus or infant. Consult your doctor immediately.
Dosage adjustments may be necessary for children; a physician should always determine the appropriate dose.
Dosage adjustments are usually necessary for patients with kidney impairment.
Patients with liver disease should use this medication with extreme caution under close medical supervision, given the risk of hepatotoxicity.
Refer to the package insert for the specific medication.
Consult reputable medical websites and journals for additional information.
