Isoniazid

An antibiotic that specifically targets mycobacterium tuberculosis.

Rifampicin

Another antibiotic effective against mycobacterium tuberculosis and other bacteria.

Treatment of active pulmonary tuberculosis (TB)

Treatment of latent tuberculosis infection (LTBI)

Prophylaxis of tuberculosis in highrisk individuals (e.g., close contacts of TB patients)

Isoniazid inhibits the synthesis of mycolic acids, essential components of the Mycobacterium tuberculosis cell wall. Rifampicin inhibits bacterial DNA-dependent RNA polymerase, thus blocking bacterial RNA synthesis and protein production. The combination of these two drugs provides a synergistic effect, enhancing their effectiveness against tuberculosis.

Store in a cool, dry place, protected from light and moisture. Keep out of reach of children. Discard any unused medication after the expiry date.

Dosage is determined by the physician based on the patient's age, weight, and the specific condition being treated.

It is crucial to complete the entire prescribed course of treatment, even if symptoms improve.

Typically administered orally, usually once daily with or without food.

Peripheral neuropathy (tingling or numbness in extremities)

Hepatotoxicity (liver damage) - rare but serious

Nausea

Vomiting

Loss of appetite

Abdominal pain

Jaundice (yellowing of skin and eyes)

Dark urine

Lightcolored stools

Fatigue

Weakness

Rash

Itching

Alcohol Consumption

Alcohol consumption can increase the risk of liver damage. Avoid alcohol while taking this medication.



While Driving or operating Machinery

Drowsiness and dizziness are potential side effects. Avoid driving or operating machinery if affected.



Pregnant & Breastfeeding Women

Discuss the risks and benefits with your doctor before taking this medication during pregnancy or breastfeeding.



Children

Dosage must be adjusted according to the child's weight and age, as prescribed by the physician.



Kidney

Kidney function should be monitored, especially in patients with pre-existing kidney disease. Dosage adjustments may be necessary.



Liver

Liver function should be monitored regularly, as liver damage is a potential, though rare, side effect. This medication should be used cautiously in patients with pre-existing liver disease.

Your prescribing physician

The prescribing information provided with the medication

Reputable medical websites such as the CDC or WHO