Rifampicin

Rifampicin (the active ingredient): A semi-synthetic antibiotic derived from rifamycin.Inactive ingredients (vary depending on the specific formulation): These may include fillers, binders, and other excipients. Always check the product label for a complete list.

Treatment of tuberculosis (TB), often in combination with other antiTB drugs.

Treatment of leprosy (Hansen's disease), usually in combination with other medications.

Prophylaxis (prevention) of meningococcal meningitis.

Treatment of certain bacterial infections, such as those caused by Haemophilus influenzae and Neisseria meningitidis (often in combination with other antibiotics).

Macox 300mg Cap (Rifampicin) inhibits bacterial DNA-dependent RNA polymerase, preventing bacterial RNA synthesis and ultimately bacterial growth and replication. This is a bacteriostatic effect (inhibits growth) and at high concentrations, bactericidal (kills bacteria).

Store at room temperature, away from direct sunlight and moisture. Keep out of reach of children. Discard any unused medication after the expiration date.

Dosage is determined by the physician based on the specific infection, patient age, weight, and renal/hepatic function.

Rifampicin is usually administered orally, but intravenous formulations may also exist. Always follow your doctor's instructions carefully.

Complete the full course of treatment, even if you feel better, to prevent recurrence of infection.

Orange-red discoloration of urine, sweat, and tears (harmless but noticeable).

Jaundice (yellowing of skin and eyes – a sign of liver problems).

Nausea and vomiting.

Abdominal pain.

Loss of appetite.

Fatigue.

Headache.

Dizziness.

Rash.

Hepatitis (liver inflammation).

Flulike symptoms.

Alcohol Consumption

Alcohol may increase the risk of liver damage while taking rifampicin. Limit or avoid alcohol consumption during treatment.



While Driving or operating Machinery

Rifampicin may cause dizziness or drowsiness. Avoid driving or operating machinery if affected.



Pregnant & Breastfeeding Women

Rifampicin can cross the placenta and may be present in breast milk. Discuss the risks and benefits with your doctor before using it during pregnancy or breastfeeding.



Children

Dosage adjustments are often necessary for children. A physician should determine the appropriate dose.



Kidney

Reduced renal function may require dosage adjustment. This must be managed by a physician.



Liver

Rifampicin can cause liver damage. Liver function tests may be monitored during treatment. Patients with pre-existing liver disease require careful monitoring.

Your doctor or pharmacist.

Medication package insert.

Reputable medical websites (e.g., Mayo Clinic, NHS).