Trifluoperazine

Is an antipsychotic medication belonging to the phenothiazine class.

Trihexyphenidyl

Is an anticholinergic medication used to treat the symptoms of parkinson's disease and other movement disorders.

Treatment of acute and chronic schizophrenia and other psychotic disorders.

Management of extrapyramidal symptoms (EPS) associated with antipsychotic medications.

Relief of tremor and rigidity in Parkinson's disease.

Trifluoperazine blocks dopamine receptors in the brain, reducing dopamine activity. Trihexyphenidyl blocks acetylcholine receptors, reducing acetylcholine activity. By altering these neurotransmitter levels, the drug combination helps alleviate symptoms of psychosis and movement disorders.

Store the medication in a cool, dry place, away from direct sunlight and heat.

Dosage should be individualized based on the patient's condition and response to treatment.

The medication is typically administered orally, with or without food.

The usual starting dose is 1-2 mg of trifluoperazine and 1-2 mg of trihexyphenidyl per day.

The dose can be increased gradually, as tolerated, up to a maximum of 40 mg of trifluoperazine and 15 mg of trihexyphenidyl per day.

Neuroleptic malignant syndrome (NMS) - a rare but serious condition characterized by high fever, muscle rigidity, and altered mental status.

Drowsiness

Dry mouth

Blurred vision

Constipation

Urinary retention

Dizziness

Headache

Weight gain

Extrapyramidal symptoms (tremors, muscle spasms, restlessness)

Alcohol Consumption

Avoid alcohol consumption while taking this medication, as it may increase the risk of side effects.



While Driving or Operating Machinery

Be cautious while driving or operating machinery as this medication may cause drowsiness and dizziness.



Pregnant & Breastfeeding Women

This medication is not recommended for pregnant or breastfeeding women unless the potential benefits outweigh the risks.



Children

This medication is not approved for use in children.



Kidney

Caution is advised in patients with kidney problems.



Liver

Caution is advised in patients with liver problems.

DailyMed: https://dailymed.nlm.nih.gov/

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