Sulfate is the active ingredient in amikacin formulations. it is an aminoglycoside antibiotic.
Treatment of serious infections caused by susceptible gramnegative bacteria.
Treatment of infections caused by bacteria resistant to other aminoglycosides.
Treatment of tuberculosis (TB) in combination with other antituberculosis drugs.
Kacimark 250mg Inj (Amikacin) inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, leading to misreading of mRNA and ultimately bacterial cell death. This action is bactericidal (kills bacteria).
Store amikacin at room temperature (20-25°C) away from moisture and direct sunlight. Protect from freezing. Discard any unused portion after the expiration date.
Dosage is determined by the severity of the infection, patient's weight, and renal function.
Amikacin is typically administered intravenously or intramuscularly.
Duration of treatment varies depending on the infection and clinical response.
Always follow the instructions provided by your doctor or pharmacist.
Nephrotoxicity (kidney damage)
Ototoxicity (hearing loss, balance problems)
Nausea
Vomiting
Rash
Hypersensitivity reactions (allergic reactions)
Neuromuscular blockade (muscle weakness)
The interaction between amikacin and alcohol is not well documented, but it's advisable to avoid excessive alcohol consumption during treatment.
Amikacin may cause dizziness or other side effects that could impair alertness. Avoid driving or operating machinery if affected.
Amikacin should be used during pregnancy only if the potential benefits outweigh the risks. It is excreted in breast milk and may cause harm to the infant.
Dosage adjustments are necessary for children based on weight and renal function.
Amikacin is primarily excreted by the kidneys. Reduced renal function necessitates dose adjustments or potential discontinuation to prevent nephrotoxicity.
Amikacin does not significantly affect liver function, though liver monitoring is recommended for prolonged use.
Your doctor or pharmacist
The official prescribing information (package insert) for your amikacin formulation
Reputable medical websites like the Mayo Clinic or UpToDate (if available and appropriate)
