Itraconazole

An antifungal medication that works by inhibiting the growth of fungi.

Terbinafine

An antifungal medication that works by inhibiting the synthesis of ergosterol, a vital component of fungal cell membranes.

Treatment of onychomycosis (fungal nail infections) caused by dermatophytes, yeasts, and molds.

Treatment of tinea pedis (athlete's foot), tinea cruris (jock itch), and tinea corporis (ringworm) caused by dermatophytes.

Itraconazole inhibits fungal cytochrome P450 enzymes, disrupting ergosterol synthesis. Terbinafine directly inhibits squalene epoxidase, another key enzyme in ergosterol synthesis. The combination provides broader antifungal coverage and potentially enhanced efficacy.

Store in a cool, dry place away from direct sunlight and moisture. Keep out of reach of children. Discard any unused medication after the expiration date.

Dosage will vary depending on the specific infection and the patient's overall health. Always follow your doctor's instructions.

Oral administration: Typically taken once or twice daily with food.

Complete the full course of treatment even if symptoms improve to prevent recurrence.

Headache

Nausea

Abdominal pain

Diarrhea

Rash

Itching

Elevated liver enzymes (rare but serious)

Allergic reactions (rare but serious)

Alcohol Consumption

Avoid excessive alcohol consumption while taking this medication, as it can increase the risk of liver damage.



While Driving or operating Machinery

May cause dizziness or drowsiness in some individuals. Avoid driving or operating machinery if affected.



Pregnant & Breastfeeding Women

Consult your doctor before taking this medication if you are pregnant or breastfeeding. It's generally avoided during pregnancy and breastfeeding unless benefits outweigh risks.



Children

Use in children should be carefully considered and only prescribed by a doctor who can assess the benefits and risks.



Kidney

Dosage adjustment may be necessary for patients with impaired kidney function.



Liver

Use with caution in patients with liver disease. Regular liver function tests may be required.

Consult your physician or pharmacist for detailed prescribing information and references.

Package insert of the specific drug formulation.