Isosorbide dinitrate is a vasodilator, meaning it widens blood vessels. It works by relaxing the smooth muscles in the walls of blood vessels, allowing blood to flow more easily.

Hydralazine is also a vasodilator. It works by relaxing the smooth muscles in the walls of blood vessels, but specifically in the arteries, reducing resistance to blood flow.

This combination medication is primarily used to treat high blood pressure (hypertension).

It is also used to treat heart failure by reducing the workload on the heart.

This combination is particularly effective in patients with high blood pressure who also have heart failure.

Isosorbide dinitrate and hydralazine both work by relaxing the muscles in the walls of blood vessels, leading to vasodilation. This dilation lowers blood pressure by decreasing the resistance to blood flow. The combination of these two medications provides a synergistic effect, meaning they work better together than either drug alone.

Store this medication at room temperature, away from heat and light. Keep it in a tightly closed container. Do not store in the bathroom. Keep this medication out of reach of children and pets.

The dosage of this medication is usually determined by your doctor based on your individual needs and medical condition.

It is typically taken by mouth, usually twice a day, with or without food.

It is crucial to follow your doctor's instructions carefully and take the medication exactly as prescribed.

Do not stop taking this medication without first consulting your doctor, as it can lead to serious side effects.

If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. Do not take a double dose to make up for a missed dose.

Less common side effects include nausea, vomiting, rapid heartbeat, and shortness of breath.

Serious side effects can occur, including low blood pressure, heart attack, and stroke.

Common side effects include headache, dizziness, lightheadedness, and flushing.

Alcohol Consumption

Alcohol can worsen the side effects of this medication, especially dizziness and lightheadedness. Avoid consuming alcohol while taking this medication.



While Driving or Operating Machinery

This medication can cause dizziness and lightheadedness, which can affect your ability to drive or operate machinery. Avoid driving or operating machinery until you know how this medication affects you.



Pregnant & Breastfeeding Women

This medication is not recommended for use during pregnancy, as it can harm the unborn baby. It is also not recommended for use while breastfeeding, as it can pass into breast milk.



Children

This medication is not typically recommended for use in children.



Kidney

If you have kidney problems, your doctor may need to adjust your dosage of this medication.



Liver

If you have liver problems, your doctor may need to adjust your dosage of this medication.

https://www.ncbi.nlm.nih.gov/pubmed/

https://www.fda.gov/

https://www.mayoclinic.org/