Glibenclamide

A sulfonylurea drug that helps your pancreas release more insulin, a hormone that lowers blood sugar levels.

Metformin

A biguanide drug that lowers blood sugar by reducing the production of glucose by the liver and improving insulin sensitivity.

Pioglitazone

A thiazolidinedione drug that increases insulin sensitivity by acting on cells that are resistant to insulin.

Type 2 diabetes mellitus when diet and exercise alone are not enough to control blood sugar levels.

May be used in combination with other diabetes medications.

This medication works by improving your body's response to insulin. It helps your pancreas release more insulin and makes your body's cells more sensitive to insulin, which helps lower your blood sugar levels.

Store at room temperature, away from moisture and direct sunlight. Keep out of reach of children.

The dosage of this medication is individualized and will be determined by your doctor based on your condition and response to treatment.

Typically taken orally, usually with meals.

Follow your doctor's instructions carefully.

Do not change the dosage or stop taking this medication without consulting your doctor.

Low blood sugar (hypoglycemia): Symptoms include sweating, dizziness, weakness, hunger, headache, confusion, and seizures.

Gastrointestinal problems: Nausea, vomiting, diarrhea, abdominal pain.

Weight gain.

Fluid retention.

Bone fractures.

Heart failure.

Liver problems.

Allergic reactions: Skin rash, itching, swelling.

Alcohol Consumption

Alcohol can interfere with the effectiveness of this medication and increase the risk of low blood sugar. Avoid excessive alcohol consumption.



While Driving or Operating Machinery

This medication can cause low blood sugar, which can affect your ability to drive or operate machinery. Be cautious and avoid driving or operating machinery if you experience symptoms of low blood sugar.



Pregnant & Breastfeeding Women

This medication is not recommended for pregnant or breastfeeding women as it can potentially harm the fetus or infant. Consult your doctor for alternative treatment options.



Children

This medication is not approved for use in children.



Kidney

This medication may be harmful to people with kidney problems. Your doctor will adjust your dosage if you have kidney disease.



Liver

This medication may be harmful to people with liver problems. Your doctor will monitor your liver function if you have liver disease.

https://www.mayoclinic.org/diseases-conditions/type-2-diabetes/diagnosis-treatment/drc-20351199

https://www.diabetes.org/diabetes-basics/diabetes-treatment-medications

https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-fda-requests-manufacturers-update-labels-metformin-medications-explain-risk