Prescription Required.Why?
A sulfonylurea drug that stimulates the pancreas to release more insulin.
A biguanide drug that improves insulin sensitivity and reduces glucose production by the liver.
Type 2 diabetes mellitus (noninsulin-dependent diabetes) in adults, especially when diet and exercise alone are insufficient to control blood sugar levels.
Used when monotherapy with either gliclazide or metformin is not providing adequate glycemic control.
Gliclazide enhances insulin secretion from the pancreas, while metformin improves insulin sensitivity in peripheral tissues and reduces hepatic glucose production. Their combined action leads to better blood sugar control.
Store in a cool, dry place, protected from light and moisture. Keep out of reach of children.
Dosage should be determined by a physician based on individual needs and response to treatment.
Typically started at a low dose and gradually increased as tolerated.
Taken with meals to minimize gastrointestinal side effects.
Hypoglycemia (low blood sugar): Symptoms include sweating, tremors, dizziness, and confusion.
Gastrointestinal disturbances: Nausea, vomiting, diarrhea, and abdominal pain (more common with metformin).
Lactic acidosis (rare but serious): Characterized by weakness, fatigue, muscle pain, and difficulty breathing. Seek immediate medical attention if suspected.
Weight gain (possible with gliclazide).
Allergic reactions: Skin rash, itching, swelling.
Alcohol can increase the risk of lactic acidosis and hypoglycemia. Limit alcohol intake while taking this medication.
Hypoglycemia can impair alertness and reaction time. Avoid driving or operating machinery if experiencing symptoms of low blood sugar.
Generally not recommended during pregnancy and breastfeeding. Consult a doctor for alternative options.
Not recommended for use in children.
Dosage adjustments may be necessary for patients with kidney disease. Close monitoring is crucial.
Use with caution in patients with liver disease. Liver function tests may be needed.
Consult your doctor or pharmacist for detailed information and references.
Check the medication's package insert for specific instructions.
