Glimepiride

A sulfonylurea oral antidiabetic drug that stimulates the pancreas to release more insulin.

Metformin

A biguanide oral antidiabetic drug that improves insulin sensitivity and reduces glucose production by the liver.

Type 2 diabetes mellitus, particularly when diet and exercise alone are not sufficient to control blood sugar levels.

Used in patients who need to lower blood glucose levels and improve glycemic control.

Glimepiride increases insulin secretion from the pancreas, while metformin enhances insulin sensitivity in peripheral tissues and reduces hepatic glucose production. The combination provides a synergistic effect in controlling blood glucose levels.

Store at room temperature, away from moisture and direct sunlight. Keep out of reach of children.

Dosage should be determined by a healthcare professional based on individual needs and response to treatment.

Generally, the medication is taken with meals to minimize gastrointestinal side effects.

Dosage adjustments may be needed based on blood glucose monitoring and overall health.

Hypoglycemia (low blood sugar): Symptoms include dizziness, sweating, shakiness, confusion, and rapid heartbeat.

Gastrointestinal disturbances (nausea, vomiting, diarrhea, abdominal pain, metallic taste)

Weight gain

Allergic reactions (rash, itching, swelling)

Vitamin B12 deficiency (longterm use)

Alcohol Consumption

Alcohol consumption should be limited or avoided as it can increase the risk of hypoglycemia and lactic acidosis.



Driving or Operating Machinery

Patients should avoid driving or operating machinery if they experience hypoglycemia.



Pregnant & Breastfeeding Women

Not recommended during pregnancy or breastfeeding. Consult a doctor immediately if pregnancy is planned or suspected.



Children

Generally not recommended for use in children.



Kidney

Use with caution in patients with kidney disease; dosage adjustment may be necessary.



Liver

Use with caution in patients with liver disease; dosage adjustment may be necessary.

Your doctor or pharmacist

The medication's package insert

Reputable medical websites (e.g., Mayo Clinic, NHS)