Pregabalin is an anticonvulsant medication that works by affecting the way certain nerves in the brain and spinal cord function.

Duloxetine is a serotonin-norepinephrine reuptake inhibitor (SNRI) antidepressant that works by increasing the levels of serotonin and norepinephrine in the brain.

Treatment of diabetic peripheral neuropathic pain (pain caused by nerve damage related to diabetes).

Treatment of fibromyalgia (a disorder characterized by widespread musculoskeletal pain, fatigue, and sleep problems).

Treatment of generalized anxiety disorder (GAD).

Treatment of major depressive disorder (MDD) in adults.

Pregabalin and duloxetine work together to reduce pain and improve mood. Pregabalin targets nerve pain signals, while duloxetine increases levels of neurotransmitters that regulate mood, pain, and sleep.

Store the medication at room temperature, away from moisture and light. Keep it out of reach of children and pets.

The dosage and frequency of administration vary depending on the individual patient and the specific condition being treated.

It is important to take the medication exactly as prescribed by your doctor.

The medication is typically taken orally, with or without food.

Drowsiness

Dizziness

Fatigue

Nausea

Dry mouth

Constipation

Weight gain

Increased appetite

Sweating

Blurred vision

Sexual dysfunction

Withdrawal symptoms upon abrupt discontinuation

Alcohol Consumption

Alcohol may enhance the sedative effects of pregabalin and duloxetine. It is advisable to avoid alcohol consumption while taking this medication.



While Driving or operating Machinery

This medication can cause drowsiness and dizziness. Avoid driving or operating machinery until you know how this medication affects you.



Pregnant & Breastfeeding Women

This medication may harm an unborn baby. Discuss your options with your doctor if you are pregnant or breastfeeding.



Children

This medication is not generally recommended for children.



Kidney

Patients with kidney problems may require dose adjustments. Discuss this with your doctor.



Liver

Patients with liver problems may require dose adjustments. Discuss this with your doctor.

https://www.medicinenet.com/pregabalin/article.htm

https://www.webmd.com/drugs/2/drug-6817/pregabalin-oral/details

https://www.drugs.com/mtm/pregabalin.html

https://www.mayoclinic.org/diseases-conditions/fibromyalgia/symptoms-causes/syc-20355018

https://www.mayoclinic.org/diseases-conditions/diabetic-neuropathy/symptoms-causes/syc-20370691

https://www.mayoclinic.org/diseases-conditions/generalized-anxiety-disorder/symptoms-causes/syc-20350960

https://www.mayoclinic.org/diseases-conditions/major-depressive-disorder/symptoms-causes/syc-20353982