Amifostine

Is the active ingredient in the drug formulation.

Amifostine is used to help protect healthy tissues from the damaging effects of chemotherapy, specifically those used to treat certain types of cancer.

It is also being investigated for use in protecting against radiation damage, especially in the context of radiation therapy for cancer.

The specific types of cancer and chemotherapy regimens for which amifostine is indicated should be discussed with your doctor.

Ethyfos 500mg Injection (Amifostine) is a cytoprotective agent. It works by reducing the toxic effects of chemotherapy and radiation on normal tissues. Specifically, it acts as a free radical scavenger, protecting cells from the damaging effects of reactive oxygen species (ROS) generated during chemotherapy and radiation. Amifostine is converted to its active form in the body, which helps to protect healthy cells from damage.

Store Amifostine at room temperature, away from direct sunlight and moisture.

Amifostine is typically administered intravenously (IV) by a healthcare professional.

The specific dosage and frequency of administration will depend on the type of chemotherapy or radiation therapy being received, as well as your individual health condition.

Always follow your doctor's instructions carefully.

The most common side effects of Amifostine include low blood pressure, nausea, vomiting, and flushing.

More serious side effects can occur, but are less frequent. These include allergic reactions, kidney problems, and low blood cell counts.

Alcohol Consumption

It is recommended to avoid alcohol consumption while taking Amifostine, as it can increase the risk of side effects.



While Driving or operating Machinery

Amifostine can cause drowsiness or dizziness, so it is important to avoid driving or operating machinery until you know how it affects you.



Pregnant & Breastfeeding Women

Amifostine should be used with caution in pregnant women, as it may harm the developing fetus. It is not recommended for breastfeeding women, as it is excreted in breast milk.



Children

Amifostine is not typically used in children, as safety and effectiveness have not been established.



Kidney

Amifostine can cause kidney problems in some people. If you have kidney disease, you may need to be closely monitored while taking Amifostine.



Liver

Amifostine can affect the liver, so it is important to monitor your liver function regularly while taking this medication.

National Cancer Institute: https://www.cancer.gov/publications/dictionaries/cancer-drug/amifostine

Drugs.com: https://www.drugs.com/mtm/amifostine.html

Mayo Clinic: https://www.mayoclinic.org/diseases-conditions/cancer/in-depth/cancer-treatment/art-20046079