Epalrestat

An aldose reductase inhibitor used to manage diabetic neuropathy.

Methylcobalamin

A form of vitamin b12 crucial for nerve function and metabolism.

Pregabalin

An anticonvulsant and analgesic medication often used to treat nerve pain.

Diabetic neuropathy (pain and numbness in the limbs)

Management of neuropathic pain associated with diabetes

Epalrestat inhibits aldose reductase, reducing the accumulation of sorbitol in nerve cells, thus alleviating nerve damage. Methylcobalamin supports nerve function and myelin sheath maintenance. Pregabalin modulates calcium channels, reducing neurotransmitter release and pain signaling.

Store in a cool, dry place, away from direct sunlight and moisture. Keep out of reach of children. Discard any unused medication according to your pharmacist's instructions.

Dosage should always be determined by a physician based on individual needs and response.

Always follow your doctor's prescribed dosage and administration schedule.

Do not alter your dosage without consulting with your doctor.

Nausea

Dizziness

Headache

Somnolence (sleepiness)

Weight gain

Peripheral edema (swelling in the extremities)

Constipation

Dry mouth

Visual disturbances (blurred vision)

Allergic reactions (rash, itching, swelling)

Alcohol Consumption

Alcohol may increase the risk of side effects, particularly drowsiness and dizziness. Consult your physician.



While Driving or operating Machinery

Avoid driving or operating machinery until you know how this medication affects you, due to the potential for drowsiness and dizziness.



Pregnant & Breastfeeding Women

This combination should be used with extreme caution during pregnancy and breastfeeding. Consult your physician for guidance.



Children

Safety and efficacy in children have not been established.



Kidney

Renal impairment may necessitate dosage adjustment. Close monitoring is required.



Liver

Hepatic impairment may necessitate dosage adjustment. Close monitoring is required.

Consult your physician or pharmacist for specific references and further information. This information should not be considered a substitute for professional medical advice.