Prescription Required.Why?
Is the primary active ingredient. specific formulations may contain inactive ingredients like sodium chloride or mannitol; always check the product label for a complete list.
Treatment of acute massive pulmonary embolism (PE)
Treatment of deep vein thrombosis (DVT) when thrombolysis is indicated
Dissolution of clots in various other conditions (as determined by a physician)
Urokinase may also be used offlabel for certain other conditions, however, this should be done only under strict medical supervision.
Dukinase 50000iu Injection (Urokinase) is a thrombolytic agent (clot-buster). It activates plasminogen, converting it to plasmin, an enzyme that breaks down fibrin, the protein that forms blood clots. This action leads to clot lysis (dissolution).
Store at the temperature specified on the product label. Usually this is refrigeration. Protect from light and moisture. Dispose of unused medication properly according to your local regulations.
Dosage is highly individualized and depends on the specific condition, severity, and patient factors. It's administered intravenously (IV) by healthcare professionals only. Never self-administer urokinase.
The dosage regimen should be strictly followed as directed by your physician. Do not alter the dosage or frequency without consulting your physician.
Continuous monitoring by healthcare providers is essential during treatment with urokinase.
Hypotension (low blood pressure)
Nausea
Vomiting
Fever
Allergic reactions (rash, itching, swelling)
Anaphylaxis (severe, lifethreatening allergic reaction)
Alcohol consumption should be avoided or limited significantly during treatment with urokinase due to increased risk of bleeding.
Driving or operating machinery may be impaired due to potential side effects like hypotension or allergic reactions. Patients should follow their physician's advice.
Use during pregnancy and breastfeeding is generally avoided unless the potential benefits outweigh the risks. Consult your physician for guidance.
Urokinase's use in children is usually determined based on the specific needs and risks assessed by a pediatric specialist.
Caution is necessary in patients with kidney impairment as the drug's excretion may be affected.
Urokinase use needs to be carefully managed in patients with liver disease. Physician evaluation is crucial.
Refer to the specific product monograph provided by your healthcare professional.
Consult reputable medical databases like PubMed for scientific information on urokinase.
