Methotrexate

Is the main active ingredient. specific formulations may contain additional inactive ingredients such as preservatives, stabilizers, or fillers, which vary depending on the product and route of administration (e.g., oral tablets, injection).

Rheumatoid arthritis

Psoriatic arthritis

Ankylosing spondylitis

Juvenile idiopathic arthritis

Certain types of cancer (e.g., choriocarcinoma, lymphoma, leukemia)

Severe psoriasis (when other treatments have failed)

Ectopic pregnancy (under strict medical supervision)

Dermotrex Gel 30gm (Methotrexate) inhibits dihydrofolate reductase, an enzyme crucial for DNA synthesis and cell division. This slows down the rapid growth of cells, particularly those in the immune system (in autoimmune diseases) or cancerous cells. It also has other complex anti-inflammatory effects.

Store at room temperature, away from light and moisture. Protect from freezing. Always follow the specific storage instructions provided with your prescription.

Dosage is highly individualized and determined by your doctor based on your condition, weight, and response to treatment. It can be administered orally, intramuscularly, or intravenously.

Never adjust your dosage without consulting your doctor.

Follow your doctor's instructions carefully regarding the frequency and timing of your doses.

Nausea

Vomiting

Diarrhea

Mouth sores

Fatigue

Hair loss

Liver damage (rare but serious)

Kidney damage (rare but serious)

Increased risk of infection

Alcohol Consumption

Avoid excessive alcohol consumption, as it can increase the risk of liver damage.



While Driving or operating Machinery

Methotrexate can cause fatigue and dizziness. Avoid driving or operating machinery if affected.



Pregnant & Breastfeeding Women

Methotrexate is highly teratogenic (causes birth defects). It is contraindicated in pregnancy. Breastfeeding should be avoided while on Methotrexate.



Children

Dosage is carefully adjusted for children, with close monitoring for side effects.



Kidney

Methotrexate is excreted through the kidneys; renal function should be monitored, especially in patients with kidney disease.



Liver

Methotrexate can cause liver damage; liver function tests are routinely monitored.

Your doctor or pharmacist

The prescribing information (package insert) that comes with your medication

Reputable medical websites (e.g., those of national medical associations or government health agencies)