Methotrexate

Is the primary active ingredient. specific formulations may contain inactive ingredients such as preservatives, fillers, and stabilizers. always check the product label for a complete list of ingredients.

Rheumatoid arthritis

Psoriatic arthritis

Ankylosing spondylitis

Juvenile idiopathic arthritis

Certain types of cancer (e.g., choriocarcinoma, lymphoma, leukemia)

Severe psoriasis

Ectopic pregnancy

Dermatrax 5mg Tab (Methotrexate) is an antifolate. It works by inhibiting dihydrofolate reductase, an enzyme crucial for DNA synthesis and cell replication. By blocking this enzyme, methotrexate slows down the growth of rapidly dividing cells, including cancer cells and immune cells involved in inflammatory diseases.

Store methotrexate at room temperature, away from moisture and light. Keep it out of reach of children. Discard any unused medication according to your doctor's or pharmacist's instructions.

Dosage varies greatly depending on the condition being treated and the patient's individual needs.

Methotrexate can be administered orally, intravenously, or intramuscularly.

Never adjust your dosage or frequency without consulting your doctor.

Follow your doctor's instructions precisely regarding dosage and administration schedule.

Nausea

Vomiting

Mouth sores

Diarrhea

Fatigue

Headache

Hair loss

Liver damage

Kidney damage

Bone marrow suppression

Increased risk of infection

Pulmonary toxicity

Alcohol Consumption

Alcohol consumption may increase the risk of liver damage. Avoid excessive alcohol while taking methotrexate.



While Driving or Operating Machinery

Methotrexate can cause fatigue, dizziness, or other side effects that may impair your ability to drive or operate machinery. Avoid these activities if affected.



Pregnant & Breastfeeding Women

Methotrexate is teratogenic (causes birth defects) and should not be used during pregnancy. It is also not recommended during breastfeeding. Discuss your reproductive plans with your doctor before starting methotrexate.



Children

Methotrexate is used in children for certain conditions, but dosage and monitoring are carefully controlled by a physician.



Kidney

Methotrexate is excreted by the kidneys. Individuals with impaired kidney function require careful monitoring and dose adjustment.



Liver

Methotrexate can cause liver damage. Regular liver function tests are necessary during treatment.

Your physician

Your pharmacist

The prescribing information for your specific methotrexate formulation

Reputable medical websites (e.g., Mayo Clinic, NIH)