Deferasirox (the active ingredient)Inactive ingredients (vary by formulation – check product label for specifics)
Treatment of chronic iron overload due to blood transfusions (transfusional hemosiderosis) in patients with betathalassemia major and other anemias.
Treatment of chronic iron overload in patients with nontransfusion-dependent thalassemias and other anemias who require chelation therapy.
Defrijet 500mg Tab (Deferasirox) is an oral iron chelator. It works by binding to iron in the body and promoting its excretion in the urine and feces, thereby reducing the amount of iron stored in organs like the heart, liver, and pancreas. This helps prevent or reduce damage caused by iron overload.
Store at room temperature (20°C to 25°C or 68°F to 77°F). Protect from moisture. Keep out of reach of children.
Dosage is determined by the physician based on individual factors, including the degree of iron overload, kidney function, and other health conditions.
It's typically administered orally, once daily with food.
Always follow your doctor's instructions precisely. Never change your dose without consulting your doctor.
Nausea
Vomiting
Diarrhea
Abdominal pain
Rash
Elevated liver enzymes (liver function tests)
Hearing loss (rare)
Eye problems (rare)
Alcohol consumption may increase the risk of liver damage. Limit or avoid alcohol while taking deferasirox.
Deferasirox may cause dizziness or fatigue in some patients. Avoid driving or operating machinery if affected.
Deferasirox should only be used during pregnancy or breastfeeding if the potential benefits outweigh the potential risks to the mother and child. Discuss with your doctor.
Dosage and safety must be carefully monitored by a physician in pediatric patients.
Patients with impaired kidney function may require dose adjustments or close monitoring. Deferasirox can cause kidney problems; regular monitoring of kidney function is necessary.
Patients with liver disease may require close monitoring of liver function tests because Deferasirox can affect the liver. Liver function should be monitored regularly.
Please consult your doctor or pharmacist for specific references and further information.
Check the official drug monograph from relevant regulatory agencies (e.g., FDA, EMA).
