Disulfiram

Is the active ingredient in medications like antabuse.

Disulfiram is used to help people with alcohol use disorder (AUD) by making them feel very sick if they drink alcohol.

It is a type of medication known as an aversive agent.

Cronodol 500mg Tab (Disulfiram) works by blocking the enzyme aldehyde dehydrogenase, which is involved in the breakdown of alcohol in the body. When this enzyme is blocked, alcohol builds up in the bloodstream, leading to unpleasant side effects such as nausea, vomiting, flushing, headache, and rapid heartbeat. This reaction can be severe, making alcohol consumption very uncomfortable, and thus deterring people from drinking.

Store disulfiram at room temperature, between 68°F and 77°F (20°C and 25°C). Keep it in a tightly closed container and away from light and moisture. Do not store in the bathroom or other humid areas. Keep disulfiram out of reach of children and pets.

Disulfiram is usually taken once a day, but the dosage may vary depending on your individual needs.

It is important to follow your doctor's instructions carefully.

Disulfiram is typically taken orally as a tablet or capsule.

Common side effects include: metallic taste in the mouth, drowsiness, fatigue, headache, and skin rash.

Serious side effects can occur, including: liver problems, nerve damage, and mental health issues.

Alcohol Consumption

Do not drink any alcohol while taking disulfiram. Even a small amount can cause a severe reaction.



While Driving or operating Machinery

Disulfiram can cause drowsiness, so it's important to avoid driving or operating machinery until you know how the medication affects you.



Pregnant & Breastfeeding Women

Disulfiram is not recommended for use during pregnancy or while breastfeeding, as it can harm the developing baby.



Children

Disulfiram is not approved for use in children.



Kidney

People with kidney problems should use disulfiram with caution, as it may be processed differently by the body.



Liver

People with liver problems should not use disulfiram, as it can further damage the liver.

U.S. National Library of Medicine: https://medlineplus.gov/druginfo/meds/a682002.html

National Institute on Alcohol Abuse and Alcoholism: https://www.niaaa.nih.gov/

Food and Drug Administration (FDA): https://www.fda.gov/