Isoniazid

An antibiotic that targets the bacteria that cause tuberculosis.

Pyrazinamide

Another antibiotic effective against tuberculosis bacteria.

Rifampicin

A broad-spectrum antibiotic also used in treating tuberculosis and other bacterial infections.

Treatment of tuberculosis (TB), specifically pulmonary TB and other forms of TB disease.

Part of a multidrug regimen to combat drug-resistant TB strains (in consultation with a physician).

The three drugs work synergistically. Isoniazid inhibits the synthesis of mycolic acids, essential components of the mycobacterial cell wall. Pyrazinamide's mechanism isn't fully understood, but it's believed to interfere with bacterial metabolism. Rifampicin inhibits bacterial DNA-dependent RNA polymerase, thus blocking bacterial RNA synthesis.

Store in a cool, dry place, away from direct sunlight and moisture. Keep out of reach of children. Always follow the specific storage instructions provided by your pharmacist.

Dosage is determined by a physician based on individual factors (age, weight, liver/kidney function).

Usually taken once daily, but the regimen can vary.

Precisely follow the prescribed dose, frequency, and duration of treatment; do not discontinue the medication without consulting your doctor.

Should be taken with food to minimize stomach upset.

Jaundice (yellowing of skin and eyes - indication of liver damage)

Nausea, vomiting, diarrhea

Loss of appetite

Fatigue

Headache

Dizziness

Druginduced hepatitis (liver inflammation)

Allergic reactions (rash, itching, swelling)

Dark urine or lightcolored stools.

Alcohol Consumption

Alcohol consumption is strongly discouraged while taking this medication, as it can increase the risk of liver damage.



While Driving or operating Machinery

May cause dizziness or drowsiness; avoid driving or operating machinery if affected.



Pregnant & Breastfeeding Women

Inform your doctor if you are pregnant, breastfeeding, or planning to become pregnant. This medication can pass into breast milk and may have harmful effects on the infant.



Children

Dosage adjustments are necessary for children. Follow your physician's instructions.



Kidney

Kidney function should be monitored, especially in patients with pre-existing kidney disease. Dose adjustments may be needed.



Liver

Liver function tests are usually recommended before and during treatment due to the potential for liver damage.

Consult your physician or pharmacist for comprehensive details and specific references.

Refer to the patient information leaflet provided with your medication.