Hydrochloride is the active ingredient in most duloxetine formulations.
Treatment of major depressive disorder (MDD)
Treatment of generalized anxiety disorder (GAD)
Treatment of diabetic peripheral neuropathic pain
Treatment of fibromyalgia
Combac 40mg Tab (Duloxetine) is a serotonin-norepinephrine reuptake inhibitor (SNRI). It works by increasing the levels of serotonin and norepinephrine in the brain, neurotransmitters believed to play a role in mood regulation and pain perception.
Store at room temperature, away from light and moisture. Keep out of reach of children.
Dosage is determined by a healthcare professional and varies based on the condition being treated and individual patient factors.
It's usually taken once or twice daily, with or without food.
Do not stop taking duloxetine abruptly; consult your doctor for guidance on gradual discontinuation.
Nausea
Headache
Dry mouth
Constipation
Drowsiness
Insomnia
Increased sweating
Decreased appetite
Sexual dysfunction
Alcohol may exacerbate side effects such as drowsiness. Consult your doctor.
Drowsiness is a potential side effect; avoid driving or operating machinery if affected.
Consult your doctor before taking duloxetine if pregnant or breastfeeding.
Generally not recommended for children and adolescents unless specifically prescribed by a specialist.
Dosage adjustment may be needed for individuals with kidney impairment.
Dosage adjustment may be needed for individuals with liver impairment.
Your doctor or pharmacist
The medication's package insert
Reputable medical websites such as the FDA or National Institutes of Health
