A cholinesterase inhibitor that increases the levels of acetylcholine, a neurotransmitter important for memory and cognitive function.
An nmda receptor antagonist that modulates the effects of glutamate, another neurotransmitter involved in learning and memory, helping to protect brain cells from overstimulation.
Moderate to severe Alzheimer's disease: This combination is used to treat the symptoms of Alzheimer's disease when symptoms progress despite treatment with donepezil alone.
Donepezil inhibits acetylcholinesterase, increasing acetylcholine levels in the brain, improving cognitive function. Memantine blocks NMDA receptors, reducing the effects of excessive glutamate, protecting neurons from damage and improving cognitive function in a different way than donepezil. The combination aims for a synergistic effect, managing symptoms more effectively than either drug alone.
Store at room temperature (20°C to 25°C), away from moisture and direct sunlight. Keep out of reach of children. Discard any unused medication after the expiration date.
Dosage should be determined by a physician based on individual patient needs and tolerance.
Generally, the medication may be started with lower dosages of both Donepezil and Memantine and gradually increased under medical supervision.
Follow your doctor's instructions carefully regarding frequency and timing of doses.
Nausea
Vomiting
Diarrhea
Dizziness
Headache
Fatigue
Insomnia
Loss of appetite
Muscle cramps
Bradycardia (slow heart rate)
Syncope (fainting)
Hallucinations
Agitation
Confusion
Avoid excessive alcohol consumption as it may worsen side effects or interact with the medication.
Avoid driving or operating machinery until you know how this medication affects you, as dizziness and drowsiness are possible side effects.
Consult your doctor before using this medication if you are pregnant, breastfeeding, or planning to become pregnant. The safety of donepezil and memantine during pregnancy and breastfeeding has not been fully established.
Not indicated for use in children.
Renal impairment may require dose adjustments. Your doctor will monitor your kidney function.
Hepatic impairment may require dose adjustments. Your doctor will monitor your liver function.
Consult your physician or pharmacist for detailed information and references to relevant medical literature.
Package insert for the specific Donepezil/Memantine formulation prescribed by your doctor.
