Clonazepam

A benzodiazepine medication that acts as a central nervous system depressant.

Propranolol

A beta-blocker that reduces the effects of adrenaline on the heart and blood vessels.

Panic disorder with or without agoraphobia (often used when other treatments have failed)

Treatment of anxiety disorders associated with physical symptoms such as tremors or palpitations

Management of social anxiety disorder (SAD) or performance anxiety in some cases.

Offlabel use in certain situations involving acute anxiety-related symptoms, often in conjunction with other medications

Clonazepam enhances the effects of gamma-aminobutyric acid (GABA), a neurotransmitter that inhibits neuronal activity, leading to reduced anxiety and muscle relaxation. Propranolol blocks the effects of adrenaline (epinephrine) and noradrenaline (norepinephrine) on beta-adrenergic receptors, reducing heart rate, blood pressure, and tremors associated with anxiety.

Store in a cool, dry place away from direct sunlight and moisture. Keep out of reach of children. Discard any medication that is expired or shows signs of deterioration.

Dosage is strictly individualized and determined by a healthcare professional based on the patient's specific condition, response to treatment and other medical factors.

Never change the dose or stop taking the medication without consulting a doctor.

Clonazepam and Propranolol are often prescribed separately, and rarely together as a fixed-dose combination. A physician will carefully monitor for appropriate response and side effects

Changes in mood, including depression or anxiety

Drowsiness, dizziness, fatigue

Nausea, vomiting

Dry mouth

Constipation

Cognitive impairment (reduced concentration or memory)

Slowed heart rate (bradycardia)

Low blood pressure (hypotension)

Sexual dysfunction

Alcohol Consumption

Alcohol should be avoided or significantly limited as it can potentiate the sedative effects of both Clonazepam and Propranolol, increasing the risk of drowsiness, impaired coordination, and respiratory depression.



While Driving or Operating Machinery

Driving or operating heavy machinery should be avoided until the patient knows how the medication affects them. Significant drowsiness and impaired cognitive function are possible.



Pregnant & Breastfeeding Women

The use of Clonazepam and Propranolol during pregnancy and breastfeeding should be carefully considered with the guidance of a physician due to the potential risks to the fetus or infant.



Children

Use in children is often not recommended due to concerns regarding development and potential adverse effects. A pediatric specialist should be involved in prescribing decisions.



Kidney

Patients with impaired kidney function may require dose adjustments. A physician will make adjustments based on the patient's lab results.



Liver

Patients with impaired liver function may require dose adjustments. A physician will make adjustments based on the patient's lab results.

Physician's Desk Reference (PDR)

Lexicomp

Micromedex

Relevant clinical practice guidelines (links to be added based on specific guidelines in your region)