Cholestyramine resin (the active ingredient)Inactive ingredients (which vary depending on the specific brand and formulation – check your product's label for a complete list. Common inactive ingredients may include artificial sweeteners, flavors, and preservatives).
Treatment of hyperlipidemia (high cholesterol) when diet and other nonpharmacological measures have not been sufficient.
Treatment of pruritus (itching) associated with cholestasis (reduced bile flow).
Treatment of diarrhea associated with bile acid malabsorption.
Management of hypercholesterolemia in patients with homozygous familial hypercholesterolemia (a rare, severe form of high cholesterol) when combined with other lipidlowering therapies.
Choltran Sachet 5gm (Cholestyramine) is a bile acid sequestrant. It works in the intestines by binding to bile acids, preventing their reabsorption into the bloodstream. This causes the liver to use more cholesterol to produce new bile acids, effectively lowering cholesterol levels in the blood.
Store at room temperature, away from moisture and heat. Keep the container tightly closed. Discard any unused medication after the expiration date.
Dosage is determined by your doctor based on your individual needs and response to treatment. It is typically given as a powder that is mixed with water or other liquids before swallowing.
Follow your doctor's instructions carefully. Do not change your dose or stop taking the medication without consulting your doctor.
Take cholestyramine at least one hour before or four hours after taking other medications, as it can interfere with their absorption.
Constipation (very common)
Nausea
Vomiting
Bloating
Abdominal pain
Gas
Vitamin deficiencies (longterm use)
Gallstones (rare)
Alcohol consumption may worsen some side effects, especially constipation. Consult your doctor about alcohol use while taking cholestyramine.
Cholestyramine is generally not expected to impair driving or operating machinery, but you should be aware of potential side effects like dizziness or nausea and avoid these activities if they occur.
Consult your doctor before using cholestyramine if you are pregnant, breastfeeding, or planning to become pregnant. The use in pregnancy should only be considered when the potential benefit outweighs the potential risk.
Dosage is adjusted for children based on their weight and overall health. This must be done under careful medical supervision.
Cholestyramine is not primarily metabolized by the kidneys, but kidney function should be monitored, particularly in patients with pre-existing kidney disease.
Patients with severe liver disease should be carefully monitored when using cholestyramine, as it can potentially worsen liver conditions.
Package inserts for various cholestyramine products
Lexicomp
Micromedex
